ArticleLearning & memory (Cold Spring Harbor, N.Y.)2011
Subregion-specific p300 conditional knock-out mice exhibit long-term memory impairments.
Article in Learning & memory (Cold Spring Harbor, N.Y.), 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 59 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
59 citing papers in PubMed, 106 citations in OpenAlex.
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- Targeting neuronal epigenomes for brain rejuvenation.The EMBO journal · 2024Review
- Epigenetics of Fear, Anxiety and Stress - Focus on Histone Modifications.Current neuropharmacology · 2024Article
- CBP Is Required for Establishing Adaptive Gene Programs in the Adult Mouse Brain.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022Article
- Epigenetic mechanisms regulate cue memory underlying discriminative behavior.Neuroscience and biobehavioral reviews · 2022Review
- Review
- Olfactory learning and memory in the greater short-nosed fruit bat Cynopterus sphinx: the influence of conspecifics distress calls.Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology · 2021Article
- The Contribution of Epigenetic Inheritance Processes on Age-Related Cognitive Decline and Alzheimer's Disease.Epigenomes · 2021Review
- From Circuits to Chromatin: The Emerging Role of Epigenetics in Mental Health.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Review
- Histone modifications, DNA methylation, and the epigenetic code of alcohol use disorder.International review of neurobiology · 2021Article
- Epigenetic Mechanisms of Learning and Memory: Implications for Aging.International journal of molecular sciences · 2020Review
- Maternal Treadmill Exercise Reduces the Neurotoxicity of Prenatal Sevoflurane Exposure in Rats via Activation of p300 Histone Acetyltransferase.Neurochemical research · 2020Article
- p300 in Cardiac Development and Accelerated Cardiac Aging.Aging and disease · 2020Review
- KAT3-dependent acetylation of cell type-specific genes maintains neuronal identity in the adult mouse brain.Nature communications · 2020Article
- CREB signals as PBMC-based biomarkers of cognitive dysfunction: A novel perspective of the brain-immune axis.Brain, behavior, and immunity · 2019Review
- Ectopic expression of aPKC-mediated phosphorylation in p300 modulates hippocampal neurogenesis, CREB binding and fear memory differently with age.Scientific reports · 2018Article
- Adolescent alcohol exposure epigenetically regulates CREB signaling in the adult amygdala.Scientific reports · 2018Article
- Epigenetic regulation of Fgf1 transcription by CRTC1 and memory enhancement.Brain research bulletin · 2018Review
- Reducing histone acetylation rescues cognitive deficits in a mouse model of Fragile X syndrome.Nature communications · 2018Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Histone acetylation plays a critical role during long-term memory formation. Several studies have demonstrated that the histone acetyltransferase (HAT) CBP is required during long-term memory formation, but the involvement of other HAT proteins has not been extensively investigated. The HATs CBP and p300 have at least 400 described interacting proteins including transcription factors known to play a role in long-term memory formation. Thus, CBP and p300 constitute likely candidates for transcriptional coactivators in memory formation. In this study, we took a loss-of-function approach to evaluate the role of p300 in long-term memory formation. We used conditional knock-out mice in which the deletion of p300 is restricted to the postnatal phase and to subregions of the forebrain. We found that p300 is required for the formation of long-term recognition memory and long-term contextual fear memory in the CA1 area of the hippocampus and cortical areas.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.