ArticleJournal of virology2011
Environmental and antigen receptor-derived signals support sustained surveillance of the lungs by pathogen-specific cytotoxic T lymphocytes.
Article in Journal of virology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 123 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
123 citing papers in PubMed.
- Origins of CD8 tissue resident memory.Frontiers in immunology · 2026Review
- Evolving role of CD8Frontiers in immunology · 2026Review
- Article
- GPR25 promotes the formation of lung and liver tissue-resident memory CD8 T cells.Science immunology · 2025Article
- Cytokine and metabolite networks shape T cell residency and functionality at the term human maternal-fetal interface.Journal of immunology (Baltimore, Md. : 1950) · 2025Article
- Epidermal Resident Memory T Cell Fitness Requires Antigen Encounter in the Skin.bioRxiv : the preprint server for biology · 2025Article
- Inflammatory conditions shape phenotypic and functional characteristics of lung-resident memory T cells in mice.Nature communications · 2025Article
- Regulatory T Cells Require TBET to Regulate Activated CD8+ T Cells During Recovery from Influenza.American journal of respiratory cell and molecular biology · 2025Article
- Tissue-Resident Memory CD8+ T Cells: Differentiation, Phenotypic Heterogeneity, Biological Function, Disease, and Therapy.MedComm · 2025Review
- Innate acting memory Th1 cells modulate heterologous diseases.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- CD8+ Tissue-Resident Memory T Cells: Versatile Guardians of the Tissue.Journal of immunology (Baltimore, Md. : 1950) · 2024Article
- Tissue-resident memory CAR T cells with stem-like characteristics display enhanced efficacy against solid and liquid tumors.Cell reports. Medicine · 2023Article
- Unique properties of tissue-resident memory T cells in the lungs: implications for COVID-19 and other respiratory diseases.Nature reviews. Immunology · 2023Review
- Retinoic acid signaling during priming licenses intestinal CD103+ CD8 TRM cell differentiation.The Journal of experimental medicine · 2023Article
- Vaccine induced memory CD8Frontiers in immunology · 2023Article
- Tumor-resident memory T cells as a biomarker of the response to cancer immunotherapy.Frontiers in immunology · 2023Review
- Route of self-amplifying mRNA vaccination modulates the establishment of pulmonary resident memory CD8 and CD4 T cells.Science immunology · 2022Article
- CTLs Get SMAD When Pathogens Tell Them Where to Go.Journal of immunology (Baltimore, Md. : 1950) · 2022Review
- Tissue-resident memory T cells in gastrointestinal cancer immunology and immunotherapy: ready for prime time?Journal for immunotherapy of cancer · 2022Review
- Tissue resident memory T cells in the respiratory tract.Mucosal immunology · 2022Review
63 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
Abstract
Viral infections often gain access to the body of their host by exploiting areas of natural vulnerability, such as the semipermeable surfaces of mucosal tissues which are adapted for adsorption of nutrients and other diffusible molecules. Once the microbes have crossed the epithelial barrier, they can disperse to other tissues where eradication may not be possible. The best opportunity for successful immune intervention is immediately after infection while the pathogen is confined to a localized area of the body. Cytotoxic T lymphocytes (CTL) which reside at the site where the infection begins can make an important contribution to immunity by reducing early dissemination of the infection. Because the lungs provide easy access points for many pathogens to enter the body, they require protection from many complementary mechanisms, including pathogen-specific cytotoxic T cells. In this study we show that an enduring response to pathogen-derived peptide antigens facilitates sustained surveillance of the lungs by pathogen-specific CTL during the recovery from influenza virus infection. Our studies show that these processed peptide antigens reinforce expression of two homing receptors (CD69 and CD103) which help recently activated virus-specific CTL colonize the lungs during a mild inflammatory response. We suggest that this requirement for prolonged antigen presentation to reinforce local CTL responses in the lungs explains why protective cellular immunity quickly declines following influenza virus infection and other viral infections that enter the body via mucosal tissues.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.