Evidence map›Paper›PMID 21345732›Full record

ArticleTrends in parasitology2011

Malaria and trypanosome transmission: different parasites, same rules?

Laura C Pollitt, Paula MacGregor, Keith Matthews, Sarah E Reece

Abstract read
In one paragraph

Article in Trends in parasitology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Trial
  3. Article
  4. Antiprotozoal Aminosteroids fromMolecules (Basel, Switzerland) · 2025
    Article
  5. Review
  6. Article
  7. Bacteriocins: Potential for Human Health.Oxidative medicine and cellular longevity · 2021
    Review
  8. Inhibition ofJournal of experimental pharmacology · 2019
    Article
  9. Article
  10. Article
  11. Article
  12. Review
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Stress and sex in malaria parasites: Why does commitment vary?Evolution, medicine, and public health · 2013
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Laura C PollittInstitute of Evolutionary Biology, School of Biological Sciences, University of Edinburgh, UK. laura.pollitt@ed.ac.uk
Paula MacGregor
Keith Matthews
Sarah E Reece

Funding

Wellcome Trust
6 · The paper itself

Abstract

African trypanosomes produce different specialized stages for within-host replication and between-host transmission and therefore face a resource allocation trade-off between maintaining the current infection (survival) and investment into transmission (reproduction). Evolutionary theory predicts the resolution of this trade-off will significantly affect virulence and infectiousness. The application of life history theory to malaria parasites has provided novel insight into their strategies for survival and reproduction; how this framework can now be applied to trypanosomes is discussed. Specifically, predictions for how parasites trade-off investment in survival and transmission in response to variation in the within-host environment are outlined. An evolutionary approach has the power to explain why patterns of investment vary between strains and during infections, giving important insights into parasite biology.

Indexed as

Adaptation, PhysiologicalAnimalsHost-Parasite InteractionsHumansMalariaSurvival AnalysisTrypanosomiasisVirulence

Identifiers

PMID21345732
PMCPMC3087881

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.