ArticleAmerican journal of obstetrics and gynecology2011
Role of HIF-1α in maternal hyperglycemia-induced embryonic vasculopathy.
Article in American journal of obstetrics and gynecology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 29 citations in OpenAlex.
- The role of endothelial-derived factors in neural tube development: implications for organoid models.Open biology · 2025Review
- HucMSCs can alleviate abnormal vasculogenesis induced by high glucose through the MAPK signaling pathway.iScience · 2024Article
- Functional cargos of exosomes derived from Flk-1Communications biology · 2022Article
- Restoring BMP4 expression in vascular endothelial progenitors ameliorates maternal diabetes-induced apoptosis and neural tube defects.Cell death & disease · 2020Article
- HIF-1, Metabolism, and Diabetes in the Embryonic and Adult Heart.Frontiers in endocrinology · 2018Review
- Maternal diabetes modulates offspring cell proliferation and apoptosis during odontogenesis via the TLR4/NF-κB signalling pathway.Cell proliferation · 2017Article
- Embryonic defence mechanisms against glucose-dependent oxidative stress require enhanced expression of Alx3 to prevent malformations during diabetic pregnancy.Scientific reports · 2017Article
- Type 2 diabetes mellitus induces congenital heart defects in murine embryos by increasing oxidative stress, endoplasmic reticulum stress, and apoptosis.American journal of obstetrics and gynecology · 2016Article
- High glucose-induced oxidative stress represses sirtuin deacetylase expression and increases histone acetylation leading to neural tube defects.Journal of neurochemistry · 2016Article
- New development of the yolk sac theory in diabetic embryopathy: molecular mechanism and link to structural birth defects.American journal of obstetrics and gynecology · 2016Review
- Advances in revealing the molecular targets downstream of oxidative stress-induced proapoptotic kinase signaling in diabetic embryopathy.American journal of obstetrics and gynecology · 2015Review
- Cellular Stress, Excessive Apoptosis, and the Effect of Metformin in a Mouse Model of Type 2 Diabetic Embryopathy.Diabetes · 2015Article
- Oxidative stress is responsible for maternal diabetes-impaired transforming growth factor beta signaling in the developing mouse heart.American journal of obstetrics and gynecology · 2015Article
- Decoding the oxidative stress hypothesis in diabetic embryopathy through proapoptotic kinase signaling.American journal of obstetrics and gynecology · 2015Review
- The Role of Oxygen Sensors, Hydroxylases, and HIF in Cardiac Function and Disease.Oxidative medicine and cellular longevity · 2015Review
- Impaired hypoxia-inducible factor (HIF) regulation by hyperglycemia.Journal of molecular medicine (Berlin, Germany) · 2014Review
- Superoxide dismutase 1 overexpression in mice abolishes maternal diabetes-induced endoplasmic reticulum stress in diabetic embryopathy.American journal of obstetrics and gynecology · 2013Article
- Trehalose prevents neural tube defects by correcting maternal diabetes-suppressed autophagy and neurogenesis.American journal of physiology. Endocrinology and metabolism · 2013Article
- c-Jun NH2-terminal kinase 1/2 and endoplasmic reticulum stress as interdependent and reciprocal causation in diabetic embryopathy.Diabetes · 2013Article
- The possible mechanisms underlying the impairment of HIF-1α pathway signaling in hyperglycemia and the beneficial effects of certain therapies.International journal of medical sciences · 2013Review
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
objectiveMaternal diabetes adversely impacts embryonic vasculogenesis, which results in embryonic vasculopathy. The purpose of our study is to determine whether hypoxia inducible factor (HIF)-1α plays a role in diabetic embryonic vasculopathy. STUDY
designLevels of HIF-1α were determined in mouse conceptuses. Conceptuses on day 7 of pregnancy were cultured under euglycemic (150 mg/dL glucose) and hyperglycemic (300 mg/dL) conditions with or without AdCA5, or in the presence or absence of 2.0 μg/mL human recombinant thioredoxin, an endogenous antioxidant protein. AdCA5 is an adenovirus encoding a constitutively active form of HIF-1α.
resultsMaternal diabetes significantly reduced HIF-1α protein expression. The administration of 1 μL (1 × 10(7) infectious units/mL) per 1 mL culture medium AdCA5 completely reversed hyperglycemia-reduced vasculature morphological scores and vascular endothelial growth factor expression. Thioredoxin treatment reversed hyperglycemia-reduced HIF-1α levels.
conclusionWe conclude that reduced HIF-1α plays a critical role in the induction of diabetic embryonic vasculopathy, and that oxidative stress is implicated in hyperglycemia-induced HIF-1α reduction.
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