ArticleCellular signalling2011
Rap1 mediates galanin receptor 2-induced proliferation and survival in squamous cell carcinoma.
Article in Cellular signalling, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
25 citing papers in PubMed, 33 citations in OpenAlex.
- RAP1-GTPase immunostaining is altered in human precancerous and cancerous cervical lesions.Biomarkers in medicine · 2024Article
- Understanding the role of nerves in head and neck cancers - a review.Oncology reviews · 2024Review
- Article
- The 3D's of Neural Phenotypes in Oral Cancer: Distance, Diameter, and Density.Advanced biology · 2023Review
- The Galaninergic System: A Target for Cancer Treatment.Cancers · 2022Review
- Galanin mediates tumor-induced immunosuppression in head and neck squamous cell carcinoma.Cellular oncology (Dordrecht, Netherlands) · 2022Article
- Galanin Receptors (GalR1, GalR2, and GalR3) Expression in Colorectal Cancer Tissue and Correlations to the Overall Survival and Poor Prognosis of CRC Patients.International journal of molecular sciences · 2022Article
- Review
- An assembly of galanin-galanin receptor signaling network.Journal of cell communication and signaling · 2021Article
- Isomer-Specific Effects ofAnimals : an open access journal from MDPI · 2021Article
- A simple and highly efficient method for multi-allelic CRISPR-Cas9 editing in primary cell cultures.Cancer reports (Hoboken, N.J.) · 2020Article
- Colorectal Cancer Invasion and Atrophy of the Enteric Nervous System: Potential Feedback and Impact on Cancer Progression.International journal of molecular sciences · 2020Review
- Identification of aberrantly methylated differentially expressed genes in prostate carcinoma using integrated bioinformatics.Cancer cell international · 2019Article
- Perineural Invasion in Head and Neck Cancer.Journal of dental research · 2018Review
- Neuroendocrine Factors and Head and Neck Squamous Cell Carcinoma: An Affair to Remember.Disease markers · 2018Review
- Mechanisms of cancer dissemination along nerves.Nature reviews. Cancer · 2016Review
- Mechanisms of Perineural Invasion.Journal of neurological surgery. Part B, Skull base · 2016Review
- G-Protein-Coupled Receptors: Next Generation Therapeutic Targets in Head and Neck Cancer?Toxins · 2015Review
- Galanin modulates the neural niche to favour perineural invasion in head and neck cancer.Nature communications · 2015Article
- Identification of Gene and MicroRNA Signatures for Oral Cancer Developed from Oral Leukoplakia.BioMed research international · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Previously we showed that galanin, a neuropeptide, is secreted by human squamous cell carcinoma of the head and neck (SCCHN) in which it exhibits an autocrine mitogenic effect. We also showed that rap1, a ras-like signaling protein, is a critical mediator of SCCHN progression. Given the emerging importance of the galanin cascade in regulating proliferation and survival, we investigated the effect of GAL on SCCHN progression via induction of galanin receptor 2 (GALR2)-mediated rap1 activation. Studies were performed in multiple SCCHN cell lines by inducing endogenous GALR2, by stably overexpressing GALR2 and by downregulating endogenous GALR2 with siGALR2. Cell proliferation and survival, mediated by the ERK and AKT signaling cascades, respectively, were evaluated by functional and immunoblot analysis. The role of rap1 in GALR2-mediated proliferation and survival was evaluated by modulating expression. Finally, the effect of GALR2 on tumor growth was determined. GALR2 stimulated proliferation and survival via ERK and AKT activation, respectively. Knockdown or inactivation of rap1 inhibited GALR2-induced, AKT and ERK-mediated survival and proliferation. Overexpression of GALR2 promoted tumor growth in vivo. GALR2 promotes proliferation and survival in vitro, and promotes tumor growth in vivo, consistent with an oncogenic role for GALR2 in SCCHN.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.