Evidence map›Paper›PMID 21345285›Full record

ReviewExpert reviews in molecular medicine2011

Emerging paramyxoviruses: molecular mechanisms and antiviral strategies.

Hector C Aguilar, Benhur Lee

Open access · bronzeAbstract readReview
In one paragraph

Review in Expert reviews in molecular medicine, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
2.0field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 51 citations in OpenAlex.

  1. Review
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  10. MicroRNA and Nonsense Transcripts as Putative Viral Evasion Mechanisms.Frontiers in cellular and infection microbiology · 2019
    Article
  11. Article
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  14. Isolation of Tioman virus from Pteropus giganteus bat in North-East region of India.Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases · 2016
    Article
  15. Article
  16. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

Hector C AguilarDepartment of Microbiology, Immunology and Molecular Genetics, University of California-Los Angeles, CA 90095, USA.
Benhur Lee
Black AIDS Institute · USUniversity of California, Los Angeles · US

Funding

Vaccines and Diagnostics TrialsU54AI065359 · NIAID · UNIVERSITY OF CALIFORNIA-IRVINE · PI BARBOUR, ALAN G. · 2005 to 2013
$88.8M
Broad spectrum therapeutics that target the viral membraneU01AI082100 · NIAID · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI LEE, BENHUR · 2009 to 2012
$3.0M
Small Molecule Inhibitors of Nipah and Hendra Virus InfectionU01AI070495 · NIAID · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI LEE, BENHUR · 2006 to 2009
$2.8M
MOLECULAR AND CELLULAR MECHANISMS OF HOST DEFENSET32AI007495 · NIAID · BAYLOR COLLEGE OF MEDICINE · PI TAN, TSE-HUA · 1996 to 2011
$2.4M
Nipah Virus Pathobiology and Effects on Innate ImmunityR01AI060694 · NIAID · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI BAUM, LINDA G · 2005 to 2009
$1.8M
Envelope-receptor interactions in Nipah and Hendra virus pathobiologyR01AI069317 · NIAID · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI LEE, BENHUR · 2007 to 2011
$1.7M
NIAID NIH HHS AI060694NIAID NIH HHS AI065359NIAID NIH HHS AI069317NIAID NIH HHS AI07495NIAID NIH HHS AI082100NIAID NIH HHS R01 AI060694NIAID NIH HHS R01 AI069317NIAID NIH HHS T32 AI007495NIAID NIH HHS U01 AI070495NIAID NIH HHS U01 AI082100NIAID NIH HHS U54 AI065359
6 · The paper itself

Abstract

In recent years, several paramyxoviruses have emerged to infect humans, including previously unidentified zoonoses. Hendra and Nipah viruses (henipaviruses within this family) were first identified in the 1990s in Australia, Malaysia and Singapore, causing epidemics with high mortality and morbidity rates in affected animals and humans. Other paramyxoviruses, such as Menangle virus, Tioman virus, human metapneumovirus and avian paramyxovirus 1, which cause less morbidity in humans, have also been recently identified. Although the Paramyxoviridae family of viruses has been previously recognised as biomedically and veterinarily important, the recent emergence of these paramyxoviruses has focused our attention on this family. Antiviral drugs can be designed to target specific important determinants of the viral life cycle. Therefore, identifying and understanding the mechanistic underpinnings of viral entry, replication, assembly and budding will be critical in the development of antiviral therapeutic agents. This review focuses on the molecular mechanisms discovered and the antiviral strategies pursued in recent years for emerging paramyxoviruses, with particular emphasis on viral entry and exit mechanisms.

Indexed as

Drug Delivery SystemsAnimalsAntiviral AgentsHenipavirus InfectionsHumansParamyxoviridaePhylogenyVirus AttachmentAntiviral Agents

Identifiers

PMID21345285
PMCPMC3253018
OpenAlexW2143239497

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.