Evidence map›Paper›PMID 21345268›Full record

ReviewStem cell research & therapy2011

Engineering a stem cell house into a home.

Penny M Gilbert, Helen M Blau

Open access · goldAbstract readReview
In one paragraph

Review in Stem cell research & therapy, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
6.0field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 45 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Review
  6. Article
  7. Biomaterial science meets computational biology.Journal of materials science. Materials in medicine · 2015
    Article
  8. Review
  9. Article
  10. Article
  11. Article
  12. Bioengineering heart tissue for in vitro testing.Current opinion in biotechnology · 2013
    Review
  13. Review
  14. Review
  15. Article
  16. Review
  17. Article
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 2 countries.

Penny M GilbertBaxter Laboratory in Stem Cell Biology, Department of Microbiology and Immunology, Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA. penney.gilbert@gmail.com
Helen M Blau
Institute for Stem Cell Biology and Regenerative Medicine · INStanford University · US

Funding

Basic and Translational Research iPSC-based hematologic and vascular therapiesU01HL100397 · NHLBI · STANFORD UNIVERSITY · PI COOKE, JOHN P · 2009 to 2015
$7.4M
TUMOR BIOLOGYT32CA009151 · NCI · STANFORD UNIVERSITY · PI CLEARY, MICHAEL L · 1985 to 2014
$5.5M
Stem Cells for Brain and BrawnR01AG020961 · NIA · STANFORD UNIVERSITY · PI BLAU, HELEN M · 2002 to 2019
$5.0M
ACTIVATORS OF MUSCLE GENESR01AG009521 · NIA · STANFORD UNIVERSITY · PI BLAU, HELEN M · 1990 to 2014
$4.7M
Regulation of Hematopoietic Stem Cell Fate in Bioengineered NichesR01HL096113 · NHLBI · STANFORD UNIVERSITY · PI BLAU, HELEN M · 2009 to 2013
$2.7M
ACTIVATORS OF HUMAN MUSCLE GENESR37AG009521 · NIA · STANFORD UNIVERSITY · PI BLAU, HELEN M · 1995 to 2004
$2.3M
NCI NIH HHS CA09151NCI NIH HHS T32 CA009151NHLBI NIH HHS HL096113NHLBI NIH HHS HL100397NHLBI NIH HHS R01 HL096113NHLBI NIH HHS U01 HL100397NIA NIH HHS AG009521NIA NIH HHS AG020961NIA NIH HHS R01 AG009521NIA NIH HHS R01 AG020961
6 · The paper itself

Abstract

In the body, tissue homeostasis is established and maintained by resident tissue-specific adult stem cells (aSCs). Through preservation of bidirectional communications with the surrounding niche and integration of biophysical and biochemical cues, aSCs actively direct the regeneration of aged, injured and diseased tissues. Currently, the ability to guide the behavior and fate of aSCs in the body or in culture after prospective isolation is hindered by our poor comprehension of niche composition and the regulation it imposes. Two-and three-dimensional biomaterials approaches permit systematic analysis of putative niche elements as well as screening approaches to identify novel regulatory mechanisms governing stem cell fate. The marriage of stem cell biology with creative bioengineering technology has the potential to expand our basic understanding of stem cell regulation imposed by the niche and to develop novel regenerative medicine applications.

Indexed as

Tissue EngineeringAdult Stem CellsBiocompatible MaterialsCell CommunicationCell Culture TechniquesHumansRegenerative MedicineStem Cell NicheBiocompatible Materials

Identifiers

PMID21345268
PMCPMC3092143
OpenAlexW2031731011

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.