ArticleVeterinary research2011
NKp46 defines ovine cells that have characteristics corresponding to NK cells.
Article in Veterinary research, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 39 citations in OpenAlex.
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- The Immune Response in the Uteri and Placentae ofPathogens (Basel, Switzerland) · 2023Article
- Advantages and Challenges of Differential Immune Cell Count Determination in Blood and Milk for Monitoring the Health and Well-Being of Dairy Cows.Veterinary sciences · 2022Review
- Early Immune Initiation by Porcine Cells followingMicroorganisms · 2021Article
- Approaches to overcome flow cytometry limitations in the analysis of cells from veterinary relevant species.BMC veterinary research · 2020Article
- The Structure, Evolution, and Gene Expression Within the Caprine Leukocyte Receptor Complex.Frontiers in immunology · 2019Article
- Peste des Petits Ruminants Virus Fusion and Hemagglutinin Proteins Trigger Antibody-Dependent Cell-Mediated Cytotoxicity in Infected Cells.Frontiers in immunology · 2018Article
- Immunological Homeostasis at the Ovine Placenta May Reflect the Degree of Maternal Fetal Interaction.Frontiers in immunology · 2018Article
- Bovine cryptosporidiosis: impact, host-parasite interaction and control strategies.Veterinary research · 2017Review
- Frequency and phenotype of natural killer cells and natural killer cell subsets in bovine lymphoid compartments and blood.Immunology · 2017Article
- Inhibition of Antigen-Specific and Nonspecific Stimulation of Bovine T and B Cells by Lymphostatin from Attaching and Effacing Escherichia coli.Infection and immunity · 2017Article
- Article
- Porcine CD3(+)NKp46(+) Lymphocytes Have NK-Cell Characteristics and Are Present in Increased Frequencies in the Lungs of Influenza-Infected Animals.Frontiers in immunology · 2016Article
- NCR1 Expression Identifies Canine Natural Killer Cell Subsets with Phenotypic Similarity to Human Natural Killer Cells.Frontiers in immunology · 2016Article
- Natural killer cells in host defense against veterinary pathogens.Veterinary immunology and immunopathology · 2015Review
- Exploiting ovine immunology to improve the relevance of biomedical models.Molecular immunology · 2015Article
- The early intestinal immune response in experimental neonatal ovine cryptosporidiosis is characterized by an increased frequency of perforin expressing NCR1(+) NK cells and by NCR1(-) CD8(+) cell recruitment.Veterinary research · 2015Article
- NCR1+ cells in dogs show phenotypic characteristics of natural killer cells.Veterinary research communications · 2015Article
- Hematological shift in goat kids naturally devoid of prion protein.Frontiers in cell and developmental biology · 2015Article
- NKp46+ CD3+ cells: a novel nonconventional T cell subset in cattle exhibiting both NK cell and T cell features.Journal of immunology (Baltimore, Md. : 1950) · 2014Article
Corrections and comments
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Authors and funding
7 authors at 4 institutions in 2 countries.
Funding
Abstract
Natural killer (NK) cells are well recognized as playing a key role in innate immune defence through cytokine production and cytotoxic activity; additionally recent studies have identified several novel NK cell functions. The ability to study NK cells in the sheep has been restricted due to a lack of specific reagents. We report the generation of a monoclonal antibody specific for ovine NKp46, a receptor which in a number of mammals is expressed exclusively in NK cells. Ovine NKp46+ cells represent a population that is distinct from CD4+ and γδ+ T-cells, B-cells and cells of the monocytic lineage. The NKp46+ cells are heterogenous with respect to expression of CD2 and CD8 and most, but not all, express CD16--characteristics consistent with NK cell populations in other species. We demonstrate that in addition to populations in peripheral blood and secondary lymphoid organs, ovine NKp46+ populations are also situated at the mucosal surfaces of the lung, gastro-intestinal tract and non-gravid uterus. Furthermore, we show that purified ovine NKp46+ populations cultured in IL-2 and IL-15 have cytotoxic activity that could be enhanced by ligation of NKp46 in re-directed lysis assays. Therefore we conclude that ovine NKp46+ cells represent a population that by phenotype, tissue distribution and function correspond to NK cells and that NKp46 is an activating receptor in sheep as in other species.
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