ArticleBMC developmental biology2011
In vivo role of different domains and of phosphorylation in the transcription factor Nkx2-1.
Article in BMC developmental biology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 26 papers, 1 of them a synthesis that pooled it.
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Who cites it
26 citing papers in PubMed, 1 synthesis or guideline pooled it, 51 citations in OpenAlex.
- The molecular causes of thyroid dysgenesis: a systematic review.Journal of endocrinological investigation · 2013Pooled it
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- Resolving thyroid lineage cell trajectories merging into a dual endocrine gland in mammals.Nature communications · 2026Article
- Opposing lineage specifiers induce a protumor hybrid identity state in lung adenocarcinoma.Genes & development · 2025Article
- The molecular and cellular choreography of early mammalian lung development.Medical review (2021) · 2024Review
- Functional characterization of two novel NKX2-1 frameshift variants that cause pulmonary surfactant dysfunction.Pediatric research · 2024Article
- A case report of ectopic thyroid adenoma resection by transaxillary non-inflatable endoscopic surgery.International journal of surgery case reports · 2024Article
- The kinase PLK1 promotes the development ofScience signaling · 2022Article
- Altered pituitary morphology as a sign of benign hereditary chorea caused by TITF1/NKX2.1 mutations.Neurogenetics · 2022Article
- Hepatic incidentaloma: An asymptomatic ectopic thyroid tissue.Frontiers in endocrinology · 2022Article
- Asynchrony of Apical Polarization, Luminogenesis, and Functional Differentiation in the Developing Thyroid Gland.Frontiers in endocrinology · 2021Article
- Unraveling the Complex Interplay Between Transcription Factors and Signaling Molecules in Thyroid Differentiation and Function, From Embryos to Adults.Frontiers in endocrinology · 2021Review
- NKX2-1 re-expression induces cell death through apoptosis and necrosis in dedifferentiated thyroid carcinoma cells.PloS one · 2021Article
- Serafino Zappacosta: An Enlightened Mentor and Educator.Frontiers in immunology · 2020Article
- Transcriptional control of lung alveolar type 1 cell development and maintenance by NK homeobox 2-1.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- Mutations in the thyroid transcription factor gene NKX2-1 result in decreased expression of SFTPB and SFTPC.Pediatric research · 2018Article
- A branching morphogenesis program governs embryonic growth of the thyroid gland.Development (Cambridge, England) · 2018Article
- Pax8 controls thyroid follicular polarity through cadherin-16.Journal of cell science · 2017Article
- PDGFRα Regulates Follicular Cell Differentiation Driving Treatment Resistance and Disease Recurrence in Papillary Thyroid Cancer.EBioMedicine · 2016Article
- Erratum to: In vivo role of different domains and of phosphorylation in the transcription factor Nkx2-1.BMC developmental biology · 2016Article
Corrections and comments
- Erratum issued
Authors and funding
12 authors at 4 institutions in 1 country.
Funding
Abstract
backgroundThe transcription factor Nkx2-1 (also known as TTF-1, Titf1 or T/EBP) contains two apparently redundant activation domains and is post-translationally modified by phosphorylation. We have generated mouse mutant strains to assess the roles of the two activation domains and of phosphorylation in mouse development and differentiation.
resultsMouse strains expressing variants of the transcription factor Nkx2-1 deleted of either activation domain have been constructed. Phenotypic analysis shows for each mutant a distinct set of defects demonstrating that distinct portions of the protein endow diverse developmental functions of Nkx2-1. Furthermore, a mouse strain expressing a Nkx2-1 protein mutated in the phosphorylation sites shows a thyroid gland with deranged follicular organization and gene expression profile demonstrating the functional role of phosphorylation in Nkx2-1.
conclusionsThe pleiotropic functions of Nkx2-1 are not all due to the protein as a whole since some of them can be assigned to separate domains of the protein or to specific post-translational modifications. These results have implication for the evolutionary role of mutations in transcription factors.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.