ArticleJournal of cellular biochemistry2011
RhoB links PDGF signaling to cell migration by coordinating activation and localization of Cdc42 and Rac.
Article in Journal of cellular biochemistry, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
22 citing papers in PubMed, 36 citations in OpenAlex.
- Article
- A new single chain, genetically encoded biosensor for RhoB GTPase based on FRET, useful for live-cell imaging.bioRxiv : the preprint server for biology · 2026Article
- Vav2 promotes ductus arteriosus anatomic closure via the remodeling of smooth muscle cells by Rac1 activation.Journal of molecular medicine (Berlin, Germany) · 2023Article
- Review
- Ubiquitination-Dependent Regulation of Small GTPases in Membrane Trafficking: From Cell Biology to Human Diseases.Frontiers in cell and developmental biology · 2021Review
- Review
- The RhoB small GTPase in physiology and disease.Small GTPases · 2018Review
- Parallels between single cell migration and barrier formation: The case of RhoB and Rac1 trafficking.Small GTPases · 2018Review
- Early growth response factor-1 DNA enzyme 1 inhibits the formation of abdominal aortic aneurysm in rats.Experimental and therapeutic medicine · 2018Article
- RhoB blockade selectively inhibits autoantibody production in autoimmune models of rheumatoid arthritis and lupus.Disease models & mechanisms · 2017Article
- RhoB controls endothelial barrier recovery by inhibiting Rac1 trafficking to the cell border.The Journal of cell biology · 2016Article
- Activation of the Wnt/planar cell polarity pathway is required for pericyte recruitment during pulmonary angiogenesis.The American journal of pathology · 2015Article
- The late endosomal p14-MP1 (LAMTOR2/3) complex regulates focal adhesion dynamics during cell migration.The Journal of cell biology · 2014Article
- Increased adenovirus Type 5 mediated transgene expression due to RhoB down-regulation.PloS one · 2014Article
- α1β1 integrin/Rac1-dependent mesangial invasion of glomerular capillaries in Alport syndrome.The American journal of pathology · 2013Article
- Substrate Stiffness Regulates PDGF-Induced Circular Dorsal Ruffle Formation Through MLCK.Cellular and molecular bioengineering · 2013Article
- Computational analysis of Rho GTPase cycling.PLoS computational biology · 2013Article
- The role of endocytosis in activating and regulating signal transduction.Cellular and molecular life sciences : CMLS · 2012Review
- Role of RhoB in the regulation of pulmonary endothelial and smooth muscle cell responses to hypoxia.Circulation research · 2012Article
- RhoB controls endothelial cell morphogenesis in part via negative regulation of RhoA.Vascular cell · 2012Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
The small GTPase RhoB regulates endocytic trafficking of receptor tyrosine kinases (RTKs) and the non-receptor kinases Src and Akt. While receptor-mediated endocytosis is critical for signaling processes driving cell migration, mechanisms that coordinate endocytosis with the propagation of migratory signals remain relatively poorly understood. In this study, we show that RhoB is essential for activation and trafficking of the key migratory effectors Cdc42 and Rac in mediating the ability of platelet-derived growth factor (PDGF) to stimulate cell movement. Stimulation of the PDGF receptor-β on primary vascular smooth muscle cells (VSMCs) results in RhoB-dependent trafficking of endosome-bound Cdc42 from the perinuclear region to the cell periphery, where the RhoGEF Vav2 and Rac are also recruited to drive formation of circular dorsal and peripheral ruffles necessary for cell migration. Our findings identify a novel RhoB-dependent endosomal trafficking pathway that integrates RTK endocytosis with Cdc42/Rac localization and cell movement.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.