ArticleFunctional & integrative genomics2011
Identification of essential genes in C. jejuni genome highlights hyper-variable plasticity regions.
Article in Functional & integrative genomics, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 36 citations in OpenAlex.
- Unraveling aerotolerancy of campylobacter jejuni and campylobacter coli using a transcriptomic approach.Scientific reports · 2026Article
- Transcriptome analysis of aerotolerant and aerosensitiveFrontiers in microbiology · 2025Article
- Monitoring AMR inEFSA journal. European Food Safety Authority · 2022Article
- Generating Transposon Insertion Libraries in Gram-Negative Bacteria for High-Throughput Sequencing.Journal of visualized experiments : JoVE · 2020Article
- Essential genome of Campylobacter jejuni.BMC genomics · 2017Article
- Genome-wide fitness analyses of the foodborne pathogen Campylobacter jejuni in in vitro and in vivo models.Scientific reports · 2017Article
- Profiling ofFrontiers in microbiology · 2017Article
- Double-Serine Fluoroquinolone Resistance Mutations Advance Major International Clones and Lineages of Various Multi-Drug Resistant Bacteria.Frontiers in microbiology · 2017Review
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- Dissimilar Fitness Associated with Resistance to Fluoroquinolones Influences Clonal Dynamics of Various Multiresistant Bacteria.Frontiers in microbiology · 2016Review
- Biofilm spatial organization by the emerging pathogen Campylobacter jejuni: comparison between NCTC 11168 and 81-176 strains under microaerobic and oxygen-enriched conditions.Frontiers in microbiology · 2015Article
- Article
- Phenotypic screening of a targeted mutant library reveals Campylobacter jejuni defenses against oxidative stress.Infection and immunity · 2014Article
- Defining the metabolic requirements for the growth and colonization capacity of Campylobacter jejuni.Frontiers in cellular and infection microbiology · 2014Review
- Article
- Campylobacter jejuni pdxA affects flagellum-mediated motility to alter host colonization.PloS one · 2013Article
- A statistical framework for improving genomic annotations of prokaryotic essential genes.PloS one · 2013Article
- Transcriptional regulation of the CmeABC multidrug efflux pump and the KatA catalase by CosR in Campylobacter jejuni.Journal of bacteriology · 2012Article
- Identification of essential genes of the periodontal pathogen Porphyromonas gingivalis.BMC genomics · 2012Article
- Prediction and identification of sequences coding for orphan enzymes using genomic and metagenomic neighbours.Molecular systems biology · 2012Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
A microarray transposon-based tracking approach was used to identify Campylobacter jejuni genes which are required for cell growth at 37°C, under a microaerophilic atmosphere and on a rich Mueller-Hinton medium. A transposon-based mutant library, comprised of 7,201 individual mutants was constructed, representing 4.48× coverage of the genome. An analysis of genes lacking a transposon insertion revealed 195 essential gene candidates. The function of these genes represent many of the expected core functions of the cell, such as energy metabolism, macromolecule and cofactor biosynthesis, cell structural proteins as well as basic cell processes. Forty-nine hypothetical proteins were also identified, further underlining the importance of currently unknown proteins and pathways within C. jejuni. Unlike other bacteria, the essential genes were not uniformly distributed along the chromosome with three main regions lacking essential genes. These particular regions corresponded to known hyper-variable plasticity regions of C. jejuni genome indicating, as expected, that these regions are dispensable in any given C. jejuni strain. Overall, this work identified dispensable and essential genes in C. jejuni that will ultimately lead to a better understanding of Campylobacter physiology.
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