ArticleInternational journal of colorectal disease2011
Collagen fleeces do not improve colonic anastomotic strength but increase bowel obstructions in an experimental rat model.
Article in International journal of colorectal disease, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.
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Who cites it
12 citing papers in PubMed, 1 synthesis or guideline pooled it, 23 citations in OpenAlex.
- External coating of colonic anastomoses: a systematic review.International journal of colorectal disease · 2012Pooled it
- Extracellular Matrix Hydrogel Reduces Anastomotic Leaks in a Rodent Model of Rectal Anastomosis.The Journal of surgical research · 2025Article
- Collagen patch cover facilitates recovery of bowel function after laparoscopic colectomy.BMC surgery · 2024Observational
- Double-layer adhesives for preventing anastomotic leakage and reducing post-surgical adhesion.Materials today. Bio · 2023Article
- Coating of Intestinal Anastomoses for Prevention of Postoperative Leakage: A Systematic Review and Meta-Analysis.Frontiers in surgery · 2022Review
- Comparison of three different application routes of butyrate to improve colonic anastomotic strength in rats.International journal of colorectal disease · 2017Article
- Morphine Promotes Colonization of Anastomotic Tissues with Collagenase - Producing Enterococcus faecalis and Causes Leak.Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract · 2016Article
- Fibrinogen-thrombin collagen patch reinforcement of high-risk colonic anastomoses in rats.World journal of gastrointestinal surgery · 2016Article
- International consensus statement regarding the use of animal models for research on anastomoses in the lower gastrointestinal tract.International journal of colorectal disease · 2016Article
- Bovine pericardium patch wrapping intestinal anastomosis improves healing process and prevents leakage in a pig model.PloS one · 2014Article
- The effect of fibrin glue on the early healing phase of intestinal anastomoses in the rat.International journal of colorectal disease · 2012Article
- Healing of colonic anastomosis in rats under obstructive ileus conditions.Discoveries (Craiova, Romania)Article
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeTo investigate whether a collagen fleece kept in place by fibrin glue might seal off a colorectal anastomosis, provide reinforcement, and subsequently improve anastomotic healing.
methodsWistar rats underwent a 1-cm left-sided colonic resection followed by a 4-suture end-to-end anastomosis. They were then randomly assigned to one of three treatment groups: no additional intervention (control, n = 20), the anastomosis covered with fibrin glue (fibrin glue, n = 20), the anastomosis covered with a collagen fleece, kept in place with fibrin glue (collagen fleece, n = 21). At either 3 or 7 days follow-up, anastomotic bursting pressure was measured and tissue was obtained for histology and collagen content assessment after which animals were sacrificed.
resultsThree rats in the control (15%), three in the fibrin glue (15%), and one in the collagen group (4.8%) died due to anastomotic complications (P = 0.497). Anastomotic bursting pressures were not significantly different between groups at 3 and 7 days follow-up (P = 0.659 and P = 0.427, respectively). However, bowel obstructions occurred significantly more often in the collagen group compared to the control group (14/21 vs. 3/20, P = 0.003). Collagen contents were not different between groups, but histology showed a more severe inflammation in the collagen group compared to the other groups at both 3 and 7 days follow-up.
conclusionsA collagen fleece kept in place by fibrin glue does not improve healing of colonic anastomoses in rats. Moreover, this technique induces significantly more bowel obstructions in rats, warranting further study before being translated to a clinical setting.
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