ReviewClinical orthopaedics and related research2011
High-resolution computed tomography for clinical imaging of bone microarchitecture.
Review in Clinical orthopaedics and related research, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 127 papers, 4 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
127 citing papers in PubMed, 4 syntheses or guidelines pooled it.
- Pooled it
- Global research trends in bone tumors: a bibliometric analysis of medical imaging.Frontiers in oncology · 2025Pooled it
- Subchondral bone remodeling patterns in larger animal models of meniscal injuries inducing knee osteoarthritis - a systematic review.Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA · 2023Pooled it
- Can gray values be converted to Hounsfield units? A systematic review.Dento maxillo facial radiology · 2022Pooled it
- Article
- Photon-counting detector CT virtual monoenergetic imaging for bone mineral density quantification: Validation with Micro-CT.iScience · 2026Article
- Additively Manufactured Patient-Specific Trabecular Bone Imitations in Anatomical Bone Models for Preoperative Planning and Surgical Training: A Manufacturing Framework.Annals of biomedical engineering · 2026Article
- Novel image registration approach for combining 2D Osterix and collagen bundles images with 3D micro-CT.JBMR plus · 2026Article
- Conditional generative diffusion model for 3D trabecular bone synthesis with tunable microstructure.Journal of medical imaging (Bellingham, Wash.) · 2026Article
- CT-based subchondral bone microstructural analysis in knee osteoarthritis via MR-guided distillation learning.Frontiers in radiology · 2026Article
- Longitudinal and radial microgradients in porosity and canal diameter in femur bone and its implications for bone regeneration and bone repair implants.Frontiers in bioengineering and biotechnology · 2026Article
- Advances in the regulation of bone metabolism by central nuclei: a new perspective on the brain-bone axis.Frontiers in neuroscience · 2026Review
- TranslatingFrontiers in bioengineering and biotechnology · 2026Article
- Effect of different osteotome surgical protocols on primary implant stability in poor quality bone: an ex vivo study.Scientific reports · 2025Article
- The impact of lifestyle-based weight loss in older adults with obesity on muscle and bone health: a balancing act.Obesity (Silver Spring, Md.) · 2025Review
- Diagnostic accuracy of Dual-Energy CT in detecting traumatic vertebral bone marrow edema: a prospective comparative study with MRI in the context of a level I trauma center.Neuroradiology · 2025Article
- Coronary Computed Tomography Angiography in Heart Transplant Patients: Current Insights and Future Directions.Transplantation · 2025Review
- Evaluation of trabecular bone microstructure and cortical morphology using cone-beam and micro-CT images: impact of tube voltage setting.BMC oral health · 2025Article
- Evaluation of the Effects of Photobiomodulation on Bone Density After Placing Dental Implants: A Pilot Study Using Cone Beam CT Analysis.Clinics and practice · 2025Article
- Comparison of MDCT Imaging and HR-pQCT for Assessment of Osseus Consolidation in Symptomatic Scaphoid Non-Union Treated with Avascular Bone Grafting and Percutaneous Screw Fixation-A Prospective Clinical Pilot Study.Journal of clinical medicine · 2025Article
67 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe role of bone structure, one component of bone quality, has emerged as a contributor to bone strength. The application of high-resolution imaging in evaluating bone structure has evolved from an in vitro technology for small specimens to an emerging clinical research tool for in vivo studies in humans. However, many technical and practical challenges remain to translate these techniques into established clinical outcomes. QUESTIONS/PURPOSES: We reviewed use of high-resolution CT for evaluating trabecular microarchitecture and cortical ultrastructure of bone specimens ex vivo, extension of these techniques to in vivo human imaging studies, and recent studies involving application of high-resolution CT to characterize bone structure in the context of skeletal disease.
methodsWe performed the literature review using PubMed and Google Scholar. Keywords included CT, MDCT, micro-CT, high-resolution peripheral CT, bone microarchitecture, and bone quality.
resultsSpecimens can be imaged by micro-CT at a resolution starting at 1 μm, but in vivo human imaging is restricted to a voxel size of 82 μm (with actual spatial resolution of ~ 130 μm) due to technical limitations and radiation dose considerations. Presently, this mode is limited to peripheral skeletal regions, such as the wrist and tibia. In contrast, multidetector CT can assess the central skeleton but incurs a higher radiation burden on the subject and provides lower resolution (200-500 μm).
conclusionsCT currently provides quantitative measures of bone structure and may be used for estimating bone strength mathematically. The techniques may provide clinically relevant information by enhancing our understanding of fracture risk and establishing the efficacy of antifracture for osteoporosis and other bone metabolic disorders.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.