Trial reportJournal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine2011
Predictors of response to a nasal expiratory resistor device and its potential mechanisms of action for treatment of obstructive sleep apnea.
Trial report in Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed.
- Expiratory Positive Airway Pressure for Sleep Apnea after Stroke: A Randomized, Crossover Trial.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2016Trial
- Apnea-induced rapid eye movement sleep disruption impairs human spatial navigational memory.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Trial
- A multicenter evaluation of oral pressure therapy for the treatment of obstructive sleep apnea.Sleep medicine · 2013Trial
- Mechanisms of nasal high flow on ventilation during wakefulness and sleep.Journal of applied physiology (Bethesda, Md. : 1985) · 2013Trial
- Long-term use of a nasal expiratory positive airway pressure (EPAP) device as a treatment for obstructive sleep apnea (OSA).Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2011Trial
- Selective Continuous Positive Airway Pressure Withdrawal With Supplemental Oxygen During Slow-Wave Sleep as a Method of Dissociating Sleep Fragmentation and Intermittent Hypoxemia-Related Sleep Disruption in Obstructive Sleep Apnea.Frontiers in physiology · 2021Article
- Therapeutic CPAP Level Predicts Upper Airway Collapsibility in Patients With Obstructive Sleep Apnea.Sleep · 2017Article
- Expiratory positive airway pressure (EPAP) nasal device therapy: a welcome addition to obstructive sleep apnea syndrome therapy.Sleep & breathing = Schlaf & Atmung · 2015Article
- A review of EPAP nasal device therapy for obstructive sleep apnea syndrome.Sleep & breathing = Schlaf & Atmung · 2015Review
- Quantifying the ventilatory control contribution to sleep apnoea using polysomnography.The European respiratory journal · 2015Article
- Nasal Expiratory Positive Airway Pressure Devices (Provent) for OSA: A Systematic Review and Meta-Analysis.Sleep disorders · 2015Review
- The classical Starling resistor model often does not predict inspiratory airflow patterns in the human upper airway.Journal of applied physiology (Bethesda, Md. : 1985) · 2014Article
- Alternative approaches to treatment of Central Sleep Apnea.Sleep medicine clinics · 2014Article
- Frequency and accuracy of "RERA" and "RDI" terms in the Journal of Clinical Sleep Medicine from 2006 through 2012.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2014Article
- Innovative treatments for adults with obstructive sleep apnea.Nature and science of sleep · 2014Review
- Complex sleep apnea.Current treatment options in neurology · 2013Article
- The undervalued potential of positional therapy in position-dependent snoring and obstructive sleep apnea-a review of the literature.Sleep & breathing = Schlaf & Atmung · 2013Review
- New and unconventional treatments for obstructive sleep apnea.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2012Review
- Upper airway collapsibility and patterns of flow limitation at constant end-expiratory lung volume.Journal of applied physiology (Bethesda, Md. : 1985) · 2012Article
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
STUDY
objectiveA one-way nasal resistor has recently been shown to reduce sleep disordered breathing (SDB) in a subset of patients with Obstructive Sleep Apnea Hypopnea Syndrome (OSAHS). The purpose of this study was to examine characteristics predictive of therapeutic response to the device and provide pilot data as to its potential mechanisms of action. PATIENTS, INTERVENTIONS, AND MEASUREMENTS: 20 subjects (15M/5F, age 54 ± 12 years, BMI 33.5 ± 5.6 kg/m²) with OSAHS underwent 3 nocturnal polysomnograms (NPSG) including diagnostic, therapeutic (with a Provent® nasal valve device), and CPAP. Additional measurements included intranasal pressures and PCO₂, closing pressures (Pcrit), and awake lung volumes in different body positions.
resultsIn 19/20 patients who slept with the device, RDI was significantly reduced with the nasal valve device compared to the diagnostic NPSG (27 ± 29/h vs 49 ± 28/h), with 50% of patients having an acceptable therapeutic response. Among demographic, lung volume, or diagnostic NPSG measures or markers of collapsibility, no significant predictors of therapeutic response were found. There was a suggestion that patients with position-dependent SDB (supine RDI > lateral RDI) were more likely to have an acceptable therapeutic response to the device. Successful elimination of SDB was associated with generation and maintenance of an elevated end expiratory pressure. No single definitive mechanism of action was elucidated.
conclusionsThe present study shows that the nasal valve device can alter SDB across the full spectrum of SDB severity. There was a suggestion that subjects with positional or milder SDB in the lateral position were those most likely to respond.
Indexed as
Identifiers
21344051PMC3041626What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.