ArticleBritish journal of cancer2011
Expression of osteopontin coregulators in primary colorectal cancer and associated liver metastases.
Article in British journal of cancer, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 19 citations in OpenAlex.
- IS THERE A CLINICAL PATHOLOGICAL CORRELATION OF COLORECTAL ADENOCARCINOMA WITH THE IMMUNOHISTOCHEMICAL EXPRESSION OF OPN AND ABCB5?Arquivos brasileiros de cirurgia digestiva : ABCD = Brazilian archives of digestive surgery · 2021Article
- Osteopontin expression is associated with progression and adverse prognosis in patients with resectable gastrointestinal stromal tumor.International journal of clinical and experimental pathology · 2019Article
- Circulating Levels of Osteopontin Predict Patients' Outcome after Resection of Colorectal Liver Metastases.Journal of clinical medicine · 2018Article
- Therapeutic Ablation of Gain-of-Function Mutant p53 in Colorectal Cancer Inhibits Stat3-Mediated Tumor Growth and Invasion.Cancer cell · 2018Article
- Regulatory activity based risk model identifies survival of stage II and III colorectal carcinoma.Oncotarget · 2017Article
- Relationship between osteopontin and β-catenin immunohistochemical expression and prognostic parameters of colorectal carcinoma.International journal of clinical and experimental pathology · 2015Article
- Post-operative plasma osteopontin predicts distant metastasis in human colorectal cancer.PloS one · 2015Article
- Pea3 expression promotes the invasive and metastatic potential of colorectal carcinoma.World journal of gastroenterology · 2014Article
- Biological resonance for cancer metastasis, a new hypothesis based on comparisons between primary cancers and metastases.Cancer microenvironment : official journal of the International Cancer Microenvironment Society · 2013Article
- The heterotrimeric laminin coiled-coil domain exerts anti-adhesive effects and induces a pro-invasive phenotype.PloS one · 2012Article
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9 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundA transcription regulatory complex (TRC) that includes Ets1, Ets2, PEA3 and β-catenin/T-cell factors regulates osteopontin (OPN) that is implicated in colorectal cancer (CRC) dissemination. The consistency of OPN transcriptional control between primary CRC and metastases is unclear. This study investigates expression and prognostic significance of the OPN-TRC in primary human CRC and associated colorectal liver metastases (CRLM).
methodsOsteopontin-TRC factors were assayed by digital microscopy in 38 primary CRCs and matched CRLM specimens and assessed against clinical prognosis.
resultsIn primary CRC, OPN expression intensity correlated with that of its co-activators, PEA3 (r=0.600; P<0.01), Ets1 (r=0.552; P<0.01), Ets2 (r=0.521; P<0.01) and had prognostic significance. Osteopontin intensity in primary CRC inversely correlated with the interval between diagnosis and resection of CRLM. Overall OPN intensity was lower in CRLM than primary CRC and correlations with co-activators were weaker, for example, Ets1 (P=0.047), PEA3 (P=0.022) or nonsignificant (Ets2). The ratio of OPN expression in CRLM vs primary CRC had prognostic significance.
conclusionThis study supports transcriptional control of OPN by known coregulators in both primary and secondary CRC. Weaker associations in CRLM suggest involvement of other unknown factors possibly from the liver microenvironment or resulting from additional genetic or epigenetic changes that drive tumour metastatic capability in OPN transcriptional control.
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