ArticleBritish journal of cancer2011
High BMI is significantly associated with positive progesterone receptor status and clinico-pathological markers for non-aggressive disease in endometrial cancer.
Article in British journal of cancer, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 2 of them syntheses that pooled it.
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Who cites it
28 citing papers in PubMed, 2 syntheses or guidelines pooled it, 55 citations in OpenAlex.
- Body mass index and mortality in endometrial cancer: A systematic review and meta-analysis.Gynecologic oncology · 2016Pooled it
- Obesity and endometrial cancer survival: a systematic review.International journal of obesity (2005) · 2013Pooled it
- Preoperative CA125 and metabolic factors associated with high-risk pathology in endometrial cancer.Oncology letters · 2026Article
- Maternal serum progesterone and BMI are associated with neonatal sex ratios following single frozen embryo transfer.PloS one · 2026Article
- Non-steroidal anti-inflammatory medication use and endometrial cancer survival: A population-based Norwegian cohort study.International journal of cancer · 2025Article
- Open Surgery including Lymphadenectomy without Adjuvant Therapy for Uterine-Confined Intermediate- and High-Risk Endometrioid Endometrial Carcinoma.Current oncology (Toronto, Ont.) · 2022Article
- Genome-wide association study identifies a role for the progesterone receptor in benign prostatic hyperplasia risk.Prostate cancer and prostatic diseases · 2021Article
- Endometrial biomarkers in premenopausal women with obesity: an at-risk cohort.American journal of obstetrics and gynecology · 2021Article
- Clinical value of selected markers of angiogenesis, inflammation, insulin resistance and obesity in type 1 endometrial cancer.BMC cancer · 2020Article
- Article
- Linking obesity-induced leptin-signaling pathways to common endocrine-related cancers in women.Endocrine · 2019Review
- Therapeutic Use of Metformin in Diabetes and Survival Outcomes in Endometrial Cancer Patients with DiabetesAsian Pacific journal of cancer prevention : APJCP · 2018Article
- Body Mass Index is Negatively Associated with Endometrial Cancer Stage, Regardless of Subtype and Menopausal Status.Journal of Cancer · 2018Article
- Article
- High visceral fat percentage is associated with poor outcome in endometrial cancer.Oncotarget · 2017Article
- The effect of visceral obesity on clinicopathological features in patients with endometrial cancer: a retrospective analysis of 200 Chinese patients.BMC cancer · 2016Article
- Endometrial Cancer Insulin-Like Growth Factor 1 Receptor (IGF1R) Expression Increases with Body Mass Index and Is Associated with Pathologic Extent and Prognosis.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2016Article
- PTEN loss is a context-dependent outcome determinant in obese and non-obese endometrioid endometrial cancer patients.Molecular oncology · 2015Article
- Associations between etiologic factors and mortality after endometrial cancer diagnosis: the NRG Oncology/Gynecologic Oncology Group 210 trial.Gynecologic oncology · 2015Article
- Feasibility and safety of laparoscopic surgery for obese Korean women with endometrial cancer: long-term results at a single institution.Journal of Korean medical science · 2014Article
Corrections and comments
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Authors and funding
11 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundEndometrial cancer incidence is increasing in industrialised countries. High body mass index (BMI, kg m(-2)) is associated with higher risk for disease. We wanted to investigate if BMI is related to clinico-pathological characteristics, hormone receptor status in primary tumour, and disease outcome in endometrial cancer. PATIENTS AND
methodsIn total, 1129 women primarily treated for endometrial carcinoma at Haukeland University Hospital during 1981-2009 were studied. Body mass index was available for 949 patients and related to comprehensive clinical and histopathological data, hormone receptor status in tumour, treatment, and follow-up.
resultsHigh BMI was significantly associated with low International Federation of Gynaecology and Obstetrics (FIGO) stage, endometrioid histology, low/intermediate grade, and high level of progesterone receptor (PR) mRNA by qPCR (n=150; P=0.02) and protein expression by immunohistochemistry (n=433; P=0.003). In contrast, oestrogen receptor (ERα) status was not associated with BMI. Overweight/obese women had significantly better disease-specific survival (DSS) than normal/underweight women in univariate analysis (P=0.035). In multivariate analysis of DSS adjusting for age, FIGO stage, histological subtype, and grade, BMI showed no independent prognostic impact.
conclusionHigh BMI was significantly associated with markers of non-aggressive disease and positive PR status in a large population-based study of endometrial carcinoma. Women with high BMI had significantly better prognosis in univariate analysis of DSS, an effect that disappeared in multivariate analysis adjusting for established prognostic markers. The role of PR in endometrial carcinogenesis needs to be further studied.
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