ArticleThe EMBO journal2011
Endocytosis of EphA receptors is essential for the proper development of the retinocollicular topographic map.
Article in The EMBO journal, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
17 citing papers in PubMed, 30 citations in OpenAlex.
- Ephrin-A3 is required for tonotopic map precision and auditory functions in the mouse auditory brainstem.The Journal of comparative neurology · 2021Article
- Visual Maps Development: Reconsidering the Role of Retinal Efnas and Basic Principle of Map Alignment.Frontiers in cellular neuroscience · 2018Article
- Article
- Over-Expression of Ephrin-A5 in Mice Results in Decreasing the Size of Progenitor Pool through Inducing Apoptosis.Molecules and cells · 2016Article
- Slit-Dependent Endocytic Trafficking of the Robo Receptor Is Required for Son of Sevenless Recruitment and Midline Axon Repulsion.PLoS genetics · 2015Article
- Target-independent ephrina/EphA-mediated axon-axon repulsion as a novel element in retinocollicular mapping.Neuron · 2014Article
- Dynamic control of excitatory synapse development by a Rac1 GEF/GAP regulatory complex.Developmental cell · 2014Article
- Rab5 and Rab4 regulate axon elongation in the Xenopus visual system.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
- In vivo expression of ephrinA5-Fc in mice results in cephalic neural crest agenesis and craniofacial abnormalities.Molecules and cells · 2014Article
- Connecting the retina to the brain.ASN neuro · 2014Review
- Age-associated defects in EphA2 signaling impair the migration of human cardiac progenitor cells.Circulation · 2013Article
- Eph receptor signaling and ephrins.Cold Spring Harbor perspectives in biology · 2013Review
- EphA/ephrin-A signaling is critically involved in region-specific apoptosis during early brain development.Cell death and differentiation · 2013Article
- Eph and ephrin signaling in the formation of topographic maps.Seminars in cell & developmental biology · 2012Review
- Eph/ephrin signaling in epidermal differentiation and disease.Seminars in cell & developmental biology · 2012Review
- Article
- D-Eph-ective endocytosis disrupts topographic mapping.The EMBO journal · 2011Article
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6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Endocytosis of Eph-ephrin complexes may be an important mechanism for converting cell-cell adhesion to a repulsive interaction. Here, we show that an endocytosis-defective EphA8 mutant forms a complex with EphAs and blocks their endocytosis in cultured cells. Further, we used bacterial artificial chromosome transgenic (Tg) mice to recapitulate the anterior>posterior gradient of EphA in the superior colliculus (SC). In mice expressing the endocytosis-defective EphA8 mutant, the nasal axons were aberrantly shifted to the anterior SC. In contrast, in Tg mice expressing wild-type EphA8, the nasal axons were shifted to the posterior SC, as predicted for the enhanced repellent effect of ephrinA reverse signalling. Importantly, Rac signalling was shown to be essential for EphA-ephrinA internalization and the subsequent nasal axonal repulsion in the SC. These results indicate that endocytosis of the Eph-ephrin complex is a key mechanism by which axonal repulsion is generated for proper guidance and topographic mapping.
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