ReviewMolecules (Basel, Switzerland)2011
The ups and downs of tannins as inhibitors of poly(ADP-ribose)glycohydrolase.
Review in Molecules (Basel, Switzerland), 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed, 30 citations in OpenAlex.
- Role of tannin-rich plant fractions in hepatoprotection: a nanotechnology perspective.Discover nano · 2026Review
- Unlocking the Therapeutic Potential of Ellagitannins: A Comprehensive Review of Key Representatives.Molecules (Basel, Switzerland) · 2025Review
- Selective small molecule PARG inhibitor causes replication fork stalling and cancer cell death.Nature communications · 2019Article
- Comprehensive analysis of telomerase inhibition by gallotannin.Oncotarget · 2018Article
- PARG deficiency is neither synthetic lethal with BRCA1 nor PTEN deficiency.Cancer cell international · 2016Article
- The rise and fall of poly(ADP-ribose): An enzymatic perspective.DNA repair · 2015Review
- Corilagin attenuates aerosol bleomycin-induced experimental lung injury.International journal of molecular sciences · 2014Article
- Crystallographic and biochemical analysis of the mouse poly(ADP-ribose) glycohydrolase.PloS one · 2014Article
- In vitro anti-cancer activity of chamaejasmenin B and neochamaejasmin C isolated from the root of Stellera chamaejasme L.Acta pharmacologica Sinica · 2013Article
- Host cell poly(ADP-ribose) glycohydrolase is crucial for Trypanosoma cruzi infection cycle.PloS one · 2013Article
- Article
- Herpes simplex virus 1 infection activates poly(ADP-ribose) polymerase and triggers the degradation of poly(ADP-ribose) glycohydrolase.Journal of virology · 2012Article
- Selective small molecule inhibition of poly(ADP-ribose) glycohydrolase (PARG).ACS chemical biology · 2012Article
- Tannins, peptic ulcers and related mechanisms.International journal of molecular sciences · 2012Review
- Discovery and structure-activity relationships of modified salicylanilides as cell permeable inhibitors of poly(ADP-ribose) glycohydrolase (PARG).Journal of medicinal chemistry · 2011Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
DNA damage to cells activates nuclear poly(ADP-ribose)polymerases (PARPs) and the poly(ADP-ribose) (PAR) synthesized is rapidly cleaved into ADP-ribose (ADPR) by PAR glycohydrolase (PARG) action. Naturally appearing tannin-like molecules have been implicated in specific inhibition of the PARG enzyme. This review deals with the in vitro and in vivo effects of tannins on PAR metabolism and their downstream actions in DNA damage signaling.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.