ReviewEpigenetics2011
The urban environment and mental disorders: Epigenetic links.
Review in Epigenetics, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
42 citing papers in PubMed, 1 synthesis or guideline pooled it, 109 citations in OpenAlex.
- Cities and neuroscience research: A systematic literature review.Frontiers in psychiatry · 2022Pooled it
- Folate and global health: part 5. syntheses on neuropsychiatric disorders.Journal of global health · 2026Review
- Built Environment-Modulated Epigenetics: The Epigenetic Consequences of Architecturally Mediated Allostatic Overload in the Built Environment.International journal of environmental research and public health · 2026Review
- Article
- The mediating role of depressive symptoms in the relationship between health literacy and suicide-related behaviors in middle school students.Scientific reports · 2025Article
- Which individual, social, and urban factors in early childhood predict psychopathology in later childhood, adolescence and young adulthood? A systematic review.SSM - population health · 2024Review
- Current Psychotic-Like Experiences Among Chinese College Students: Prevalence, Correlates, and Its Relationship with Suicidal Ideation.Psychology research and behavior management · 2024Article
- Are housing circumstances associated with faster epigenetic ageing?Journal of epidemiology and community health · 2023Article
- Effects of Vegetation Structure on Psychological Restoration in an Urban Rooftop Space.International journal of environmental research and public health · 2022Article
- Does Where You Live Predict What You Say? Associations between Neighborhood Factors, Child Sleep, and Language Development.Brain sciences · 2022Article
- Neighborhood environment perceptions associate with depression levels and cardiovascular risk among middle-aged and older adults: Data from the Washington, DC cardiovascular health and needs assessment.Aging & mental health · 2021Article
- Psychosocial experiences modulate asthma-associated genes through gene-environment interactions.eLife · 2021Article
- Adherence to the Mediterranean diet partially mediates socioeconomic differences in leukocyte LINE-1 methylation: evidence from a cross-sectional study in Italian women.Scientific reports · 2020Article
- Prevalence and Correlates of Psychotic Like Experiences in a Large Community Sample of Young Adults in Tunisia.Community mental health journal · 2020Article
- Perinatal mental health around the world: priorities for research and service development in China.BJPsych international · 2020Article
- How Dietary Factors Affect DNA Methylation: Lesson from Epidemiological Studies.Medicina (Kaunas, Lithuania) · 2020Review
- Association of Neighborhood Disadvantage in Childhood With DNA Methylation in Young Adulthood.JAMA network open · 2020Observational
- Inadequate socialisation, inactivity, and urban living environment are associated with social fearfulness in pet dogs.Scientific reports · 2020Article
- Associations between neighborhood-level violence and individual mental disorders: Results from the World Mental Health surveys in five Latin American cities.Psychiatry research · 2019Article
- Digging deeper in Shanghai: towards a 'mechanism-rich' epidemiology.International health · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
For the first time in human history, more than half of the world's population lives in urban areas and this is projected to increase to two-thirds by 2030. This increased urbanity of the world's population has substantial public health implications. Nearly a century of research has shown higher risk of mental disorder among persons living in urban versus rural areas. Epidemiologic research has documented that associations between particular features of the urban environment, such as concentrated disadvantage, residential segregation and social norms, contribute to the risk of mental illness. We propose that changes in DNA methylation may be one potential mechanism through which features of the urban environment contribute to psychopathology. Recent advances in animal models and human correlation studies suggest DNA methylation as a promising mechanism that can explain how the environment "gets under the skin." Aberrant DNA methylation signatures characterize mental disorders in community settings. Emerging evidence of associations between exposure to features of the environment and methylation patterns may lead toward the identification of mechanisms that explain the link between urban environments and mental disorders. Importantly, evidence that epigenetic changes are reversible offers new opportunities for ameliorating the impact of adverse urban environments on human health.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.