ArticleDevelopment (Cambridge, England)2011
Neuronal remodeling and apoptosis require VCP-dependent degradation of the apoptosis inhibitor DIAP1.
Article in Development (Cambridge, England), 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers.
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Who cites it
46 citing papers in PubMed, 75 citations in OpenAlex.
- The mRNA export factor UAP56 is required for dendrite and synapse pruning via actin regulation in Drosophila.Journal of cell science · 2026Article
- Predictive Cellular Signatures from Live Human Motor Neurons Distinguish TDP-43 ALS and Enable ALS Subtype Stratification.bioRxiv : the preprint server for biology · 2026Article
- Dendrite injury triggers neuroprotection in Drosophila models of neurodegenerative disease.Scientific reports · 2024Article
- Recent progress in dendritic pruning ofOpen biology · 2024Review
- Visualizing and Measuring Dendrite Arborization in Drosophila Somatosensory Neurons.Methods in molecular biology (Clifton, N.J.) · 2024Article
- Article
- A photo-switchable assay system for dendrite degeneration and repair inProceedings of the National Academy of Sciences of the United States of America · 2022Article
- Neuronal VCP loss of function recapitulates FTLD-TDP pathology.Cell reports · 2021Article
- DNA damage in embryonic neural stem cell determines FTLDs' fate via early-stage neuronal necrosis.Life science alliance · 2021Article
- Low FoxO expression ineLife · 2020Article
- Review
- Homeostatic Roles of the Proteostasis Network in Dendrites.Frontiers in cellular neuroscience · 2020Review
- JNK signaling coordinates with ecdysone signaling to promote pruning ofDevelopment (Cambridge, England) · 2019Article
- Regulatory and sequence evolution in response to selection for improved associative learning ability in Nasonia vitripennis.BMC genomics · 2018Article
- Beyond autophagy: a novel role for autism-linked Wdfy3 in brain mitophagy.Scientific reports · 2018Article
- Developmental and tissue specific changes of ubiquitin forms in Drosophila melanogaster.PloS one · 2018Article
- Sp110 enhances macrophage resistance toOncotarget · 2017Article
- More alive than dead: non-apoptotic roles for caspases in neuronal development, plasticity and disease.Cell death and differentiation · 2017Review
- PAR-1 promotes microtubule breakdown during dendrite pruning inThe EMBO journal · 2017Article
- Article
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
The regulated degeneration of axons or dendrites (pruning) and neuronal apoptosis are widely used during development to determine the specificity of neuronal connections. Pruning and apoptosis often share similar mechanisms; for example, developmental dendrite pruning of Drosophila class IV dendritic arborization (da) neurons is induced by local caspase activation triggered by ubiquitin-mediated degradation of the caspase inhibitor DIAP1. Here, we examined the function of Valosin-containing protein (VCP), a ubiquitin-selective AAA chaperone involved in endoplasmic reticulum-associated degradation, autophagy and neurodegenerative disease, in Drosophila da neurons. Strong VCP inhibition is cell lethal, but milder inhibition interferes with dendrite pruning and developmental apoptosis. These defects are associated with impaired caspase activation and high DIAP1 levels. In cultured cells, VCP binds to DIAP1 in a ubiquitin- and BIR domain-dependent manner and facilitates its degradation. Our results establish a new link between ubiquitin, dendrite pruning and the apoptosis machinery.
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