ArticleInfection and immunity2011
Pneumocystis infection in an immunocompetent host can promote collateral sensitization to respiratory antigens.
Article in Infection and immunity, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
15 citing papers in PubMed, 21 citations in OpenAlex.
- B cells and iBALT in TB immunity & pathogenesis.Frontiers in immunology · 2026Review
- Immune Responses toJournal of inflammation research · 2026Review
- Immune responses of different hosts toEuropean respiratory review : an official journal of the European Respiratory Society · 2025Review
- A combined immune and inflammatory indicator predict the prognosis of severe Pneumocystis jirovecii pneumonia patients: a 12-year, retrospective, observational cohort.BMC pulmonary medicine · 2024Observational
- Comparative Dosing of Adjunctive Corticosteroids Therapy forInfection and drug resistance · 2024Article
- Immune Response inJournal of fungi (Basel, Switzerland) · 2021Review
- Bronchoscopy in severe childhood asthma: Irresponsible or irreplaceable?Pediatric pulmonology · 2020Review
- Role of iBALT in Respiratory Immunity.Current topics in microbiology and immunology · 2020Review
- Increase in secreted airway mucins and partial Muc5b STAT6/FoxA2 regulation during Pneumocystis primary infection.Scientific reports · 2019Article
- Primary infection by Pneumocystis induces Notch-independent Clara cell mucin production in rat distal airways.PloS one · 2019Article
- A Novel CD4American journal of respiratory and critical care medicine · 2016Article
- Pneumocystis.Cold Spring Harbor perspectives in medicine · 2014Review
- Modulation of inflammasome-mediated pulmonary immune activation by type I IFNs protects bone marrow homeostasis during systemic responses to Pneumocystis lung infection.Journal of immunology (Baltimore, Md. : 1950) · 2013Article
- Near-universal prevalence of Pneumocystis and associated increase in mucus in the lungs of infants with sudden unexpected death.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2013Article
- Pneumocystis elicits a STAT6-dependent, strain-specific innate immune response and airway hyperresponsiveness.American journal of respiratory cell and molecular biology · 2012Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Infection with the opportunistic fungal pathogen Pneumocystis is assumed to pass without persistent pathology in immunocompetent hosts. However, when immunocompetent BALB/c mice were inoculated with Pneumocystis, a vigorous Th2-like pulmonary inflammation ensued and peaked at 14 days postinfection. This coincided with a 10-fold increase in the number of antigen-presenting cells (APCs) in the lung, and these cells were capable of presenting antigen in vitro, as well as greater uptake of antigen in vivo. When mice were presented with exogenous antigen at the 14-day time point of the infection, they developed respiratory sensitization to that antigen, in the form of increased airway hyperresponsiveness upon a later challenge, whereas mice not infected but presented with antigen did not. Like other forms of collateral sensitization, this response was dependent on interleukin-4 receptor signaling. This ability to facilitate sensitization to exogenous antigen has been previously reported for other infectious disease agents; however, Pneumocystis appears to be uniquely capable in this respect, as a single intranasal dose without added adjuvant, when it was administered at the appropriate time, was sufficient to initiate sensitization. Pneumocystis infection probably occurs in most humans during the first few years of life, and in the vast majority of cases, it fails to cause any overt direct pathology. However, as we show here, Pneumocystis can be an agent of comorbidity at this time by facilitating respiratory sensitization that may relate to the later development or exacerbation of obstructive airway disease.
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Registered trials
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