Evidence map›Paper›PMID 21343207›Full record

SynthesisBMJ (Clinical research ed.)2011

Association of alcohol consumption with selected cardiovascular disease outcomes: a systematic review and meta-analysis.

Paul E Ronksley, Susan E Brien, Barbara J Turner, Kenneth J Mukamal, William A Ghali

3 registry-linked trialsAbstract readMeta-AnalysisSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in BMJ (Clinical research ed.), 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 3 registered trials, which are not on this map. Cited by 680 papers, 19 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
680citing papers in PubMed, 19 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01864031 unknown statusnot on this map

The Role of Alcohol Consumption in the Aetiology of Different Cardiovascular Disease Phenotypes: a CALIBER Study Using Linked Electronic Health Records

TypeobservationalSponsorUniversity College, LondonRan1997 to 2014Enrolled2,240,000ConditionsChronic Stable Angina, Unstable Angina, Coronary Heart Disease Not Otherwise Specified, Acute Myocardial Infarction
NCT03416088 nacompletednot on this mapstarted 2017, after this paper: background citation

The Influence of Daily Activities on Retinal Microcirculation in Normal Adults

TypeinterventionalSponsorJiannan HuangRan2017 to 2020Enrolled54ConditionsRetinal Microcirculation DisorderArmsBeverage consumption, Daily reading, Body motion
NCT06995391 narecruitingnot on this mapstarted 2025, after this paper: background citation

Digitally Rendered Interventions And Knowledge To Limit Ethanol-Associated Atrial Fibrillation Severity

TypeinterventionalSponsorUniversity of California, San FranciscoRan2025 to 2030Enrolled1,000ConditionsAtrial Fibrillation (AF)ArmsContemporary Guideline-Adherence, Alcohol Abstinence
3 · Its place in the literature

Who cites it

680 citing papers in PubMed, 19 syntheses or guidelines pooled it.

  1. Alcohol consumption and risk of atrial fibrillation: a pairwise and network meta-analysis.Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology · 2026
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  16. Will Proton Pump Inhibitors Increase the Risk of Diabetes Mellitus? A Systemic Review and Meta-Analysis.The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology · 2022
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620 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors.

Paul E RonksleyDepartment of Community Health Sciences, Faculty of Medicine, Calgary Institute for Population and Public Health, University of Calgary, Alberta, Canada.
Susan E Brien
Barbara J Turner
Kenneth J Mukamal
William A Ghali

Funding

Canadian Institutes of Health Research
6 · The paper itself

Abstract

objectiveTo conduct a comprehensive systematic review and meta-analysis of studies assessing the effect of alcohol consumption on multiple cardiovascular outcomes.

designSystematic review and meta-analysis. DATA SOURCES: A search of Medline (1950 through September 2009) and Embase (1980 through September 2009) supplemented by manual searches of bibliographies and conference proceedings. Inclusion criteria Prospective cohort studies on the association between alcohol consumption and overall mortality from cardiovascular disease, incidence of and mortality from coronary heart disease, and incidence of and mortality from stroke. Studies reviewed Of 4235 studies reviewed for eligibility, quality, and data extraction, 84 were included in the final analysis.

resultsThe pooled adjusted relative risks for alcohol drinkers relative to non-drinkers in random effects models for the outcomes of interest were 0.75 (95% confidence interval 0.70 to 0.80) for cardiovascular disease mortality (21 studies), 0.71 (0.66 to 0.77) for incident coronary heart disease (29 studies), 0.75 (0.68 to 0.81) for coronary heart disease mortality (31 studies), 0.98 (0.91 to 1.06) for incident stroke (17 studies), and 1.06 (0.91 to 1.23) for stroke mortality (10 studies). Dose-response analysis revealed that the lowest risk of coronary heart disease mortality occurred with 1-2 drinks a day, but for stroke mortality it occurred with ≤1 drink per day. Secondary analysis of mortality from all causes showed lower risk for drinkers compared with non-drinkers (relative risk 0.87 (0.83 to 0.92)).

conclusionsLight to moderate alcohol consumption is associated with a reduced risk of multiple cardiovascular outcomes.

Indexed as

Alcohol DrinkingCardiovascular DiseasesCause of DeathCoronary DiseaseHumansIncidencePrognosisProspective StudiesRisk FactorsStroke

Identifiers

PMID21343207
PMCPMC3043109

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.