The STEP study provides a hint that vaccine induction of the right CD8+ T cell responses can facilitate immune control of HIV.

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

Who cites it

9 citing papers in PubMed.

1. Understanding the performance of HIV-1 viral vector vaccines: adenovirus and poxvirus case studies.Frontiers in immunology · 2025
   Review
2. The Effect of Treatment-Associated Mutations on HIV Replication and Transmission Cycles.Viruses · 2022
   Review
3. The use of viral vectors in vaccine development.NPJ vaccines · 2022
   Review
4. Application of Viral Vectors for Vaccine Development with a Special Emphasis on COVID-19.Viruses · 2020
   Review
5. Lower Viral Loads and Slower CD4+ T-Cell Count Decline in MRKAd5 HIV-1 Vaccinees Expressing Disease-Susceptible HLA-B*58:02.The Journal of infectious diseases · 2016
   Article
6. Virus-vectored influenza virus vaccines.Viruses · 2014
   Review
7. PD1-based DNA vaccine amplifies HIV-1 GAG-specific CD8+ T cells in mice.The Journal of clinical investigation · 2013
   Article
8. HLA-B*57 Micropolymorphism shapes HLA allele-specific epitope immunogenicity, selection pressure, and HIV immune control.Journal of virology · 2012
   Article
9. Coordinate linkage of HIV evolution reveals regions of immunological vulnerability.Proceedings of the National Academy of Sciences of the United States of America · 2011
   Article

Corrections and comments

• Comment on
  An Ad5-vectored HIV-1 vaccine elicits cell-mediated immunity but does not affect disease progression in HIV-1-infected male subjects: results from a randomized placebo-controlled trial (the Step study).2011

Authors and funding

2 authors.

Funding

Abstract

PubMed holds no abstract for this paper.

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