ArticleJournal of controlled release : official journal of the Controlled Release Society2011
Silica nanoconstruct cellular toleration threshold in vitro.
Article in Journal of controlled release : official journal of the Controlled Release Society, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
27 citing papers in PubMed, 60 citations in OpenAlex.
- Rational design of immunogenic nanoparticles as a platform to reduce ovarian tumor burden in mice.International journal of pharmaceutics · 2025Article
- Mechanisms of immune response to inorganic nanoparticles and their degradation products.Advanced drug delivery reviews · 2022Review
- One-year chronic toxicity evaluation of single dose intravenously administered silica nanoparticles in mice and their Ex vivo human hemocompatibility.Journal of controlled release : official journal of the Controlled Release Society · 2020Article
- Subchronic toxicity of silica nanoparticles as a function of size and porosity.Journal of controlled release : official journal of the Controlled Release Society · 2019Article
- The destructive spontaneous ingression of tunable silica nanosheets through cancer cell membranes.Chemical science · 2019Article
- Genotoxicity of amorphous silica nanoparticles: Status and prospects.Nanomedicine : nanotechnology, biology, and medicine · 2019Review
- Toxicity Mechanism of Low Doses of NaGdF₄:YbBiomolecules · 2019Article
- Creative use of analytical techniques and high-throughput technology to facilitate safety assessment of engineered nanomaterials.Analytical and bioanalytical chemistry · 2018Review
- Glutathione-sensitive hollow mesoporous silica nanoparticles for controlled drug delivery.Journal of controlled release : official journal of the Controlled Release Society · 2018Article
- Global gene expression analysis of macrophage response induced by nonporous and porous silica nanoparticles.Nanomedicine : nanotechnology, biology, and medicine · 2018Article
- Role of autophagy in cell-penetrating peptide transfection model.Scientific reports · 2017Article
- Facilitating Translational Nanomedicine via Predictive Safety Assessment.Molecular therapy : the journal of the American Society of Gene Therapy · 2017Review
- Redox-Responsive Polysulfide-Based Biodegradable Organosilica Nanoparticles for Delivery of Bioactive Agents.ACS applied materials & interfaces · 2017Article
- Stress fibers, autophagy and necrosis by persistent exposure to PM2.5 from biomass combustion.PloS one · 2017Article
- Differential Protein Adsorption and Cellular Uptake of Silica Nanoparticles Based on Size and Porosity.ACS applied materials & interfaces · 2016Article
- Macrophage-derived MCPIP1 mediates silica-induced pulmonary fibrosis via autophagy.Particle and fibre toxicology · 2016Article
- Autophagy upregulation promotes macrophages to escape mesoporous silica nanoparticle (MSN)-induced NF-κB-dependent inflammation.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2016Article
- Nanoparticle Uptake: The Phagocyte Problem.Nano today · 2015Article
- Macrophage silica nanoparticle response is phenotypically dependent.Biomaterials · 2015Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
The influence of geometry of silica nanomaterials on cellular uptake and toxicity on epithelial and phagocytic cells was studied. Three types of amine-terminated silica nanomaterials were prepared and characterized via the modified Stober method, namely spheres (178±27 nm), worms (232±22 nm×1348±314 nm) and cylinders (214±29 nm×428±66 nm). The findings of the study suggest that in this size range and for the cell types studied, geometry does not play a dominant role in the modes of toxicity and uptake of these particles. Rather, a concentration threshold and cell type dependent toxicity of all particle types was observed. This correlated with confocal microscopy observations, as all nanomaterials were observed to be taken up in both cell types, with a greater extent in phagocytic cells. It must be noted that there appears to be a concentration threshold at ~100 μg/mL, below which there is limited to no impact of the nanoparticles on membrane integrity, mitochondrial function, phagocytosis or cell death. Analysis of cell morphology by transmission electron microscopy, colocalization experiments with intracellular markers and Western Blot results provide evidence of potential involvement of lysosomal escape, autophagic like activity, compartmental fusion and recycling in response to intracellular nanoparticle accumulation. These processes could be involved in cellular coping or defense mechanisms. The manipulation of physicochemical properties to enhance or reduce toxicity paves the way for the safe design of silica-based nanoparticles for use in nanomedicine.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.