ArticleMicrobial biotechnology2011
Extracellular Streptomyces vesicles: amphorae for survival and defence.
Article in Microbial biotechnology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
37 citing papers in PubMed, 75 citations in OpenAlex.
- Expanding perspectives on specialized metabolism in Streptomyces bacteria.Essays in biochemistry · 2026Review
- Bacterial Extracellular Vesicles: An Emerging Concern in the Field of Environmental Contamination-Characterization, Impacts, and Response Strategies.Microorganisms · 2025Review
- Peptidoglycan-reshuffling proteins SCO0954, SCO1758, SCO4439, and SCO4440 modulate the formation of wall-deficient cells in Streptomyces coelicolor under hyperosmotic sucrose stress.Scientific reports · 2025Article
- Extracellular vesicles in bone aging: therapeutic strategies and applications.Extracellular vesicles and circulating nucleic acids · 2025Review
- Article
- Immunomodulatory Potential of Fungal Extracellular Vesicles: Insights for Therapeutic Applications.Biomolecules · 2023Review
- An update on our understanding of Gram-positive bacterial membrane vesicles: discovery, functions, and applications.Frontiers in cellular and infection microbiology · 2023Review
- Tolerance, Adaptation, and Cell Response Elicited byInternational journal of molecular sciences · 2022Article
- Membrane Organization Strategies in Vesicular Antibiotic Delivery.The Journal of membrane biology · 2022Review
- Bacterial extracellular vesicles as bioactive nanocarriers for drug delivery: Advances and perspectives.Bioactive materials · 2022Review
- The polyene antifungal candicidin is selectively packaged into membrane vesicles in Streptomyces S4.Archives of microbiology · 2022Article
- Extracellular vesicle formation in Lactococcus lactis is stimulated by prophage-encoded holin-lysin system.Microbial biotechnology · 2022Article
- Streptomyces coelicolor Vesicles: Many Molecules To Be Delivered.Applied and environmental microbiology · 2022Article
- PncsHub: a platform for annotating and analyzing non-classically secreted proteins in Gram-positive bacteria.Nucleic acids research · 2022Article
- Comparative Proteomic Analysis of Membrane Vesicles from ClinicalClinical, cosmetic and investigational dermatology · 2022Article
- The extracellular vesicle generation paradox: a bacterial point of view.The EMBO journal · 2021Review
- Metabolome Analysis of Constituents in Membrane Vesicles forMicroorganisms · 2021Article
- Pathogenesis Mediated by Bacterial Membrane Vesicles.Sub-cellular biochemistry · 2021Article
- Deacylation of Calcium-Dependent Antibiotics from Streptomyces violaceoruber in Co-culture with Streptomyces sp. MG7-G1.Chembiochem : a European journal of chemical biology · 2020Article
- Extracellular vesicles: An emerging platform in gram-positive bacteria.Microbial cell (Graz, Austria) · 2020Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Blue-pigmented exudates arise as droplets on sporulated lawns of Streptomyces coelicolor M110 grown on agar plates. Our electron microscopical and biochemical studies suggest that droplets contain densely packed vesicles with large assemblies of different protein types and/or the polyketide antibiotic actinorhodin. Frozen-hydrated vesicles were unilamellar with a typical bilayer membrane, and ranged from 80 to 400 nm in diameter with a preferred width of 150-300 nm. By means of cryo-electron tomography, three types were reconstructed three-dimensionally: vesicles that were filled with particulate material, likely protein assemblies, those that contained membrane-bound particles, and a vesicle that showed a higher contrast inside, but lacked particles. Our LC/MS analyses of generated tryptic peptides led to the identification of distinct proteins that carry often a predicted N-terminal signal peptide with a twin-arginine motif or lack a canonical signal sequence. The proteins are required for a range of processes: the acquisition of inorganic as well as organic phosphate, iron ions, and of distinct carbon sources, energy metabolism and redox balance, defence against oxidants and tellurites, the tailoring of actinorhodin, folding and assembly of proteins, establishment of turgor, and different signalling cascades. Our novel findings have immense implications for understanding new avenues of environmental biology of streptomycetes and for biotechnological applications.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.