ReviewMicrobial biotechnology2011
Cross-talk of global nutritional regulators in the control of primary and secondary metabolism in Streptomyces.
Review in Microbial biotechnology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers.
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Who cites it
50 citing papers in PubMed, 97 citations in OpenAlex.
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- Regulatory and metabolic control of microbial biosynthetic gene clusters.Communications biology · 2026Review
- MarinePharmaceuticals (Basel, Switzerland) · 2026Article
- Mechanistic insights into ammonium-driven metabolic regulation for enhanced nemadectin biosynthesis in Streptomyces cyaneogriseus.Bioresources and bioprocessing · 2026Article
- Defining the networks that connect RNase III and RNase J-mediated regulation of primary and specialized metabolism inJournal of bacteriology · 2025Article
- One Strain Many Compounds Approach for Anti-ACS omega · 2025Article
- Cultivation methods and biology of Lentinula edodes.Applied microbiology and biotechnology · 2025Review
- Structural insights into transcription regulation of the global OmpR/PhoB family regulator PhoP from Mycobacterium tuberculosis.Nature communications · 2025Article
- Unveiling the role of the PhoP master regulator in arsenite resistance throughCurrent research in microbial sciences · 2025Article
- Metabolomics Approach to Explore Bioactive Natural Products Derived From Plant-Root-Associated Streptomyces.Applied biochemistry and biotechnology · 2024Article
- Structural insights into transcription activation of theiScience · 2024Article
- What is the role of microbial biotechnology and genetic engineering in medicine?MicrobiologyOpen · 2024Review
- Unlocking the potential of bacterial endophytes from medicinal plants for drug discovery.Microbial biotechnology · 2024Review
- Tolyporphins-Exotic Tetrapyrrole Pigments in a Cyanobacterium-A Review.Molecules (Basel, Switzerland) · 2023Review
- Flux balance analysis-based metabolic modeling of microbial secondary metabolism: Current status and outlook.PLoS computational biology · 2023Review
- Research progress on GlnR-mediated regulation in Actinomycetes.Frontiers in microbiology · 2023Review
- Two-Component Systems ofInternational journal of molecular sciences · 2022Review
- Comparative Proteomic Analysis of Transcriptional and Regulatory Proteins Abundances inInternational journal of molecular sciences · 2022Article
- Curation, inference, and assessment of a globally reconstructed gene regulatory network for Streptomyces coelicolor.Scientific reports · 2022Article
- Strategies of organic phosphorus recycling by soil bacteria: acquisition, metabolism, and regulation.Environmental microbiology reports · 2022Review
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Limitation of different nutrients in Streptomyces coelicolor A3(2) triggers nutrient-stress responses, mediated by PhoP, GlnR, AfsR and other regulators, that are integrated at the molecular level and control secondary metabolite biosynthesis and differentiation. In addition, utilization of chitin or N-acetylglucosamine regulates secondary metabolite biosynthesis by a mechanism mediated by DasR. Phosphate control of primary and secondary metabolism in Streptomyces species is mediated by the two-component PhoR-PhoP system. In S. coelicolor, PhoP controls secondary metabolism by binding to a PHO box in the afsS promoter overlapping with the AfsR binding site. Therefore, the afsS promoter serves to integrate the PhoP-mediated response to phosphate limitation and AfsR-mediated responses to other unknown environmental stimuli. Interestingly, phosphate control oversees nitrogen regulation but not vice versa. In ΔphoP mutants, expression of some nitrogen metabolism genes including glnA, glnII and glnK is increased. Phosphate control of these genes is exerted through binding of PhoP to the promoters of glnR (the global nitrogen regulator), glnA, glnII and the amtB-glnK-glnD operon. This regulation allows a 'metabolic homeostasis' of phosphate and nitrogen utilization pathways, preventing nutritional unbalances. Similar mechanisms of interaction between phosphate control and carbon catabolite regulation or between phosphate and DasR-mediated N-acetylglucosamine regulation appear to exist. Transport of N-acetylglucosamine by the NagE2 permease and, therefore, regulation of secondary metabolism, is dependent upon the balance of phosphorylated/dephosphorylated proteins of the N-acetylglucosamine phosphotransferase system. These findings provide the bases for understanding the mechanisms underlying systems biology of Streptomyces species.
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