ReviewJournal of nursing scholarship : an official publication of Sigma Theta Tau International Honor Society of Nursing2011
Emerging biobehavioral factors of fatigue in sickle cell disease.
Review in Journal of nursing scholarship : an official publication of Sigma Theta Tau International Honor Society of Nursing, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
25 citing papers in PubMed, 2 syntheses or guidelines pooled it, 51 citations in OpenAlex.
- Measurement of fatigue in sickle cell disease: a systematic review of fatigue measures.Orphanet journal of rare diseases · 2025Pooled it
- Academic Performance of Children With Sickle Cell Disease in the United States: A Meta-Analysis.Frontiers in neurology · 2021Pooled it
- Sleep disturbance, depression and pain in adults with sickle cell disease.BMC psychiatry · 2014Trial
- "It's like going through life at a mediocre level": a qualitative study of the meaning and impact of fatigue in children and young people with sickle cell disease.BMC pediatrics · 2025Article
- Preliminary data examining associations of fatigue subtypes with pain, pain interference, sleep quality, and affect across 14 days in adolescents with chronic musculoskeletal pain and pain-free controls.Journal of pediatric psychology · 2025Article
- Evaluating fatigue and excessive daytime sleepiness: a comparative analysis of prevalence and correlating factors in interstitial lung disease patients and healthy controls.Annals of medicine · 2024Article
- Late effects of hemopoietic stem cell transplant for sickle cell disease: monitoring and management.Expert review of hematology · 2024Review
- Illness Intrusiveness in Adults with Sickle Cell Disease: The Role of Fatigue.Journal of clinical psychology in medical settings · 2023Article
- Fatigue, Stress Appraisal, and Emotional Functioning Among Youth With Sickle Cell Disease: A Daily Diary Study.Journal of pediatric psychology · 2023Article
- Sleep and fatigue among youth with sickle cell disease: A daily diary study.Journal of behavioral medicine · 2023Article
- Research knowledge transfer to improve the care and support of adolescents with sickle cell disease in Ghana.Health expectations : an international journal of public participation in health care and health policy · 2022Article
- Article
- Sickle cell disease chronic joint pain: Clinical assessment based on maladaptive central nervous system plasticity.Frontiers in medicine · 2022Review
- Impact of sickle cell disease on patients' daily lives, symptoms reported, and disease management strategies: Results from the international Sickle Cell World Assessment Survey (SWAY).American journal of hematology · 2021Article
- Factors associated with fatigue in hip and/or knee osteoarthritis: a systematic review and best evidence synthesis.Rheumatology advances in practice · 2021Article
- Voxelotor: alteration of sickle cell disease pathophysiology by a first-in-class polymerization inhibitor.Therapeutic advances in hematology · 2021Review
- Developmental Profile of Sleep and Its Potential Impact on Daytime Functioning from Childhood to Adulthood in Sickle Cell Anaemia.Brain sciences · 2020Article
- Sleep Moderating the Relationship Between Pain and Health Care Use in Youth With Sickle Cell Disease.The Clinical journal of pain · 2020Article
- Investigating the Sleep-Pain Relationship in Youth with Sickle Cell Utilizing mHealth Technology.Journal of pediatric psychology · 2019Article
- Temporal relationship between daily pain and actigraphy sleep patterns in pediatric sickle cell disease.Journal of behavioral medicine · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
purposeThe symptom most frequently associated with sickle cell disease (SCD) is pain, but recent research is beginning to indicate that fatigue as an increasingly important symptom of this disease upon which to focus research efforts. This article explores biological and behavioral factors that can potentially contribute to fatigue in SCD. ORGANIZING FRAMEWORK: A biobehavioral framework guides this discussion of factors that may contribute to SCD fatigue.
findingsThe pathophysiology of the disease process, such as the profound hemolytic anemia and unpredictable vasoocclusive crises, suggests that individuals with SCD are at risk for both acute and chronic fatigue. For example, hypoxemia can cause muscle weakness and produce oxidative stress, which, in turn, increases fatigue. Sickled erythrocytes disrupt the vascular endothelium and stimulate proinflammatory cytokines, which are linked to sleep disruptions. Pain, the most notorious symptom of SCD, has a complex and mechanistically poorly understood relationship with fatigue.
conclusionsLittle is known about the symptom of fatigue in SCD. Considering the biological and behavioral factors of SCD that could potentially contribute to fatigue, there is a great need for research on the nature and potential mechanisms of fatigue in SCD. CLINICAL RELEVANCE: Fatigue in SCD may negatively affect quality of life. Understanding factors that may contribute to fatigue aids the clinician in identifying causes and determining treatment.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.