ArticleBiomacromolecules2011
Poly(ethylene glycol) microparticles produced by precipitation polymerization in aqueous solution.
Article in Biomacromolecules, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed.
- Facile Microfluidic Fabrication of Biocompatible Hydrogel Microspheres in a Novel Microfluidic Device.Molecules (Basel, Switzerland) · 2022Article
- Controlling Structure with Injectable Biomaterials to Better Mimic Tissue Heterogeneity and Anisotropy.Advanced healthcare materials · 2021Review
- Methods for Generating Hydrogel Particles for Protein Delivery.Annals of biomedical engineering · 2016Review
- Characteristics of precipitation-formed polyethylene glycol microgels are controlled by molecular weight of reactants.Journal of visualized experiments : JoVE · 2013Article
- An approach for lacidipine loaded gastroretentive formulation prepared by different methods for gastroparesis in diabetic patients.Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society · 2013Article
- Clickable Poly(ethylene glycol)-Microsphere-Based Cell Scaffolds.Macromolecular chemistry and physics · 2013Article
- Modular poly(ethylene glycol) scaffolds provide the ability to decouple the effects of stiffness and protein concentration on PC12 cells.Acta biomaterialia · 2011Article
- Bottom-up tissue engineering.Current opinion in biotechnology · 2011Review
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
Methods were developed to perform precipitation photopolymerization of PEG-diacrylate. Previously, comonomers have been added to PEG when precipitation polymerization was desired. In the present method, the LCST of the PEG itself was lowered by the addition of the kosmotropic salt sodium sulfate to an aqueous solution. Typical of a precipitation polymerization, small microparticles or microspheres (1-5 μm) resulted with relatively low polydispersity. However, aggregate formation was often severe, presumably because of a lack of stabilization of the phase-separated colloids. Microparticles were also produced by copoymerization of PEG-diacrylate with acrylic acid or aminoethylmethacrylate. The comonomers affected the zeta potential of the formed microparticles but not the size. The carboxyl groups of acrylic-acid-containing PEG microparticles were activated, and scaffolds were formed by mixing with amine-containing PEG microparticles. Although the scaffolds were relatively weak, human hepatoma cells showed excellent viability when present during microparticle cross-linking.
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Registered trials
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