SynthesisDiabetologia2011
Haemoglobin A1c levels and subsequent cardiovascular disease in persons without diabetes: a meta-analysis of prospective cohorts.
Synthesis in Diabetologia, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 5 of them syntheses that pooled it.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed, 5 syntheses or guidelines pooled it, 52 citations in OpenAlex.
- Potential Markers of Dietary Glycemic Exposures for Sustained Dietary Interventions in Populations without Diabetes.Advances in nutrition (Bethesda, Md.) · 2020Pooled it
- Development of type 2 diabetes mellitus in people with intermediate hyperglycaemia.The Cochrane database of systematic reviews · 2018Pooled it
- HbA1c and Risks of All-Cause and Cause-Specific Death in Subjects without Known Diabetes: A Dose-Response Meta-Analysis of Prospective Cohort Studies.Scientific reports · 2016Pooled it
- Pooled it
- Circulating biomarkers for predicting cardiovascular disease risk; a systematic review and comprehensive overview of meta-analyses.PloS one · 2013Pooled it
- The glycosylated hemoglobin level and the severity of cardiovascular involvement in patients with the first episode of acute coronary syndrome.Caspian journal of internal medicine · 2024Article
- Loneliness and HbA1c among older Irish couples: Retirement as life stage context.Personal Relationships · 2022Article
- Dyadic Loneliness and Changes to HbA1c Among Older US Couples: The Role of Marital Support as Stress Buffer.Journal of aging and health · 2021Article
- Dose-response analysis between hemoglobin A1c and risk of atrial fibrillation in patients with and without known diabetes.PloS one · 2020Article
- Relative contributions of preprandial and postprandial glucose exposures, glycemic variability, and non-glycemic factors to HbANutrition & diabetes · 2018Article
- Diabetes Mellitus and Ischemic Heart Disease: The Role of Ion Channels.International journal of molecular sciences · 2018Review
- Cardiovascular Risk Factors in Patients with Poorly Controlled Diabetes Mellitus.Medical archives (Sarajevo, Bosnia and Herzegovina) · 2018Article
- Can Cardiovascular Epidemiology and Clinical Trials Close the Risk Management Gap Between Diabetes and Prediabetes?Current diabetes reports · 2017Review
- The optimal cutoff value of glycated hemoglobin for detection of diabetic retinopathy.Diabetes & metabolism journal · 2015Review
- Sulfonylurea use and incident cardiovascular disease among patients with type 2 diabetes: prospective cohort study among women.Diabetes care · 2014Article
- Impact of an integrated obesity management system on patient's care - research protocol.BMC obesity · 2014Article
- HbA1c for diagnosis of type 2 diabetes. Is there an optimal cut point to assess high risk of diabetes complications, and how well does the 6.5% cutoff perform?Diabetes, metabolic syndrome and obesity : targets and therapy · 2013Review
- Association of glycated albumin with the presence of carotid plaque in patients with type 2 diabetes.Journal of diabetes investigation · 2013Article
- Monounsaturated fatty acids and risk of cardiovascular disease: synopsis of the evidence available from systematic reviews and meta-analyses.Nutrients · 2012Review
- The worldwide epidemiology of type 2 diabetes mellitus--present and future perspectives.Nature reviews. Endocrinology · 2011Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 5 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aims/hypothesisThe aim of this meta-analysis was to determine the relationship between HbA(1c) levels and subsequent cardiovascular outcomes in individuals without diabetes.
methodsWe searched Medline, Embase and Scopus from initiation of the study until the end of 2009. One reviewer searched and another verified findings. Data were extracted by one reviewer and verified by another. We accepted prospective studies in any language reporting three or more quartiles for HbA(1c) levels. Within quartiles, authors must have presented both numbers of patient-years at risk and cardiovascular outcomes. Outcomes per person-time at risk were regressed on average HbA(1c) values using Poisson regression. We pooled β coefficients using Cochran's semi-weighted (inverse variance) random-effects model. Study quality was assessed using the Downs-Black scale.
resultsWe investigated 16 datasets (nine for total cardiovascular events and seven for death) from five papers with 44,158 patients (44% men) over 404,899 patient-years of follow-up. There were 1,366 cardiovascular deaths (3.1%; 3.37/1,000 person-years) and 2,142 cardiovascular events (4.9%; 5.29/1,000 person-years). The overall meta-analytic β coefficients were 0.720 (95% CI 0.307-1.133) and 0.757 (95% CI 0.382-1.132) for cardiac death and events, respectively. Compared with the baseline value of 0.0427, an HbA(1c) level of 0.05 was associated with a relative risk for cardiovascular death of 1.13 (95% CI 1.05-1.21), a 0.06 value with 1.34 (95% CI 1.13-1.58), and a 0.07 HbA(1c) with relative risk 1.58 (95% CI 1.22-2.06). Results for total cardiovascular events were similar. The average study quality was 0.7 (70%). CONCLUSIONS/
interpretationWe conclude that HbA(1c) was significantly associated with cardiovascular events and deaths in persons without diabetes.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.