Evidence map›Paper›PMID 21340453›Full record

ArticleEuropean journal of nuclear medicine and molecular imaging2011

Duration of 18F-FDG avidity in lymph nodes after pandemic H1N1v and seasonal influenza vaccination.

Anders Thomassen, Anne Lerberg Nielsen, Oke Gerke, Allan Johansen, Henrik Petersen

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In one paragraph

Article in European journal of nuclear medicine and molecular imaging, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
45citing papers in PubMed, 1 pooled it
1.0field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

45 citing papers in PubMed, 1 synthesis or guideline pooled it, 77 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Trial
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  6. Article
  7. Prolonged generalized immune response onRadiology case reports · 2023
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  9. NovelJournal of nuclear medicine : official publication, Society of Nuclear Medicine · 2023
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  10. Axillary Lymph Node Uptake onMolecular imaging and radionuclide therapy · 2023
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  11. Article
  12. Review
  13. Temporary Reactive Response of Axillary Lymph Nodes to COVID-19 Vaccination onJournal of nuclear medicine : official publication, Society of Nuclear Medicine · 2022
    Article
  14. Article
  15. Article
  16. Article
  17. Absolute Lymphocyte Count After COVID-19 Vaccination Is Associated with Vaccine-Induced Hypermetabolic Lymph Nodes onJournal of nuclear medicine : official publication, Society of Nuclear Medicine · 2022
    Article
  18. Article
  19. Review
  20. IncreasedMolecular imaging and radionuclide therapy · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Anders ThomassenDepartment of Nuclear Medicine, OUH, Odense University Hospital, 5000 Odense C, Denmark. anders.thomassen@ouh.regionsyddanmark.dk
Anne Lerberg Nielsen
Oke Gerke
Allan Johansen
Henrik Petersen
Odense University Hospital · DK

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeThe aim of our study was to investigate the occurrence of fluorodeoxyglucose (FDG) avidity in draining axillary lymph nodes after vaccination against influenza (H1N1v pandemic and seasonal) and to determine the period of increased FDG uptake.

methodsDuring December 2009, patients referred for (18)F-FDG positron emission tomography (PET)/CT scans (n = 293) filled in a questionnaire concerning vaccination type (seasonal and/or H1N1v), time and anatomical localization of vaccination. Only injections in deltoid regions were evaluated, thus ensuring that draining lymph nodes were axillary. If more vaccinations had been given, only the latest vaccination was evaluated in each deltoid region.

resultsOf all patients who underwent PET/CT scans during December 2009, 26% had been vaccinated with at least one influenza vaccination in the deltoid region. A total of 92 'draining' and 60 'reference' (i.e. contralateral, non-vaccinated) axillary lymph nodes were evaluated in 61 patients (19 of 61 patients were scanned twice). The maximal intensity in FDG uptake (SUV(max)) in draining lymph nodes was 5 g/ml body weight (BW), whereas the maximal intensity in reference lymph nodes was 1.9 g/ml BW. The SUV(max) was normalized approximately 40 days after vaccination. No significant enlargement of metabolically active draining lymph nodes could be demonstrated on CT scan. Chemotherapy or immunosuppressive drugs given within 2 weeks from vaccination did not affect SUV(max) in the axillary lymph nodes.

conclusionInfluenza vaccination may lead to FDG-avid draining lymph nodes beyond 1 month.

Indexed as

SeasonsVaccinationAdolescentAdultAgedAged, 80 and overBiological TransportChildFemaleFluorodeoxyglucose F18HumansInfluenza A Virus, H1N1 SubtypeInfluenza, HumanLymph NodesMaleMiddle AgedFluorodeoxyglucose F18

Identifiers

PMID21340453
OpenAlexW1991378124

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.