Trial reportPloS one2011
Transcranial electrical currents to probe EEG brain rhythms and memory consolidation during sleep in humans.
Trial report in PloS one, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 83 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
83 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Towards optimized methodological parameters for maximizing the behavioral effects of transcranial direct current stimulation.Frontiers in human neuroscience · 2024Pooled it
- The Effects of Transcranial Electrical Stimulation of the Brain on Sleep: A Systematic Review.Frontiers in psychiatry · 2021Pooled it
- Quantitative Electroencephalography Characteristics for Parkinson's Disease: A Systematic Review.Journal of Parkinson's disease · 2020Pooled it
- The effects of transcranial direct current stimulation (tDCS) on subjective, autonomic and neuropsychological response in the 7.5% COJournal of psychopharmacology (Oxford, England) · 2026Trial
- The effects of eszopiclone on sleep spindles and memory consolidation in schizophrenia: a randomized clinical trial.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2020Trial
- Intermittent tACS during a visual task impacts neural oscillations and LZW complexity.Experimental brain research · 2020Trial
- Low frequency transcranial electrical stimulation does not entrain sleep rhythms measured by human intracranial recordings.Nature communications · 2017Trial
- Memory improvement via slow-oscillatory stimulation during sleep in older adults.Neurobiology of aging · 2015Trial
- The critical role of sleep spindles in hippocampal-dependent memory: a pharmacology study.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Trial
- Investigating the role of beta and gamma tACS in visual processing and conscious perception.Neuroscience of consciousness · 2026Article
- Article
- Impact of neuromodulation on excessive daytime sleepiness: a narrative review.Frontiers in psychiatry · 2025Review
- No Benefit in Memory Performance after Nocturnal Memory Reactivation Coupled with Theta-tACS.Clocks & sleep · 2024Article
- A classification-based generative approach to selective targeting of global slow oscillations during sleep.Frontiers in human neuroscience · 2024Article
- Beta spectral power during sleep is associated with impaired recall of extinguished fear.Sleep · 2023Article
- Closed-Loop tACS Delivered during Slow-Wave Sleep Reduces Retroactive Interference on a Paired-Associates Learning Task.Brain sciences · 2023Article
- Slow-oscillatory tACS does not modulate human motor cortical response to repeated plasticity paradigms.Experimental brain research · 2022Article
- Alterations of sleep oscillations in Alzheimer's disease: A potential role for GABAergic neurons in the cortex, hippocampus, and thalamus.Brain research bulletin · 2022Review
- State-dependent effects of neural stimulation on brain function and cognition.Nature reviews. Neuroscience · 2022Review
- Classification of EEG Signals Reveals a Focal Aftereffect of 10 Hz Motor Cortex Transcranial Alternating Current Stimulation.Cerebral cortex communications · 2022Article
23 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Previously the application of a weak electric anodal current oscillating with a frequency of the sleep slow oscillation (∼0.75 Hz) during non-rapid eye movement sleep (NonREM) sleep boosted endogenous slow oscillation activity and enhanced sleep-associated memory consolidation. The slow oscillations occurring during NonREM sleep and theta oscillations present during REM sleep have been considered of critical relevance for memory formation. Here transcranial direct current stimulation (tDCS) oscillating at 5 Hz, i.e., within the theta frequency range (theta-tDCS) is applied during NonREM and REM sleep. Theta-tDCS during NonREM sleep produced a global decrease in slow oscillatory activity conjoint with a local reduction of frontal slow EEG spindle power (8-12 Hz) and a decrement in consolidation of declarative memory, underlining the relevance of these cortical oscillations for sleep-dependent memory consolidation. In contrast, during REM sleep theta-tDCS appears to increase global gamma (25-45 Hz) activity, indicating a clear brain state-dependency of theta-tDCS. More generally, results demonstrate the suitability of oscillating-tDCS as a tool to analyze functions of endogenous EEG rhythms and underlying endogenous electric fields as well as the interactions between EEG rhythms of different frequencies.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.