Evidence map›Paper›PMID 21340029›Full record

SynthesisPloS one2011

A systematic review and meta-analysis of the efficacy and safety of intermittent preventive treatment of malaria in children (IPTc).

Anne L Wilson, IPTc Taskforce

3 registry-linked trialsOpen access · goldAbstract readMeta-AnalysisSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in PloS one, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 3 registered trials, which are not on this map. Cited by 84 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
84citing papers in PubMed, 4 pooled it
12.6field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02504918 completednot on this mapstarted 2015, after this paper: background citation

Markers of T Cell Suppression: Associations With Malaria Infection and Antimalarial Treatment

TypeobservationalSponsorNational Institute of Allergy and Infectious Diseases (NIAID)Ran2015 to 2018Enrolled200ConditionsMalaria
NCT03143218 phase3completednot on this mapstarted 2017, after this paper: background citation

A Phase IIIB Comparative Trial of Seasonal Vaccination With the Malaria Vaccine RTS,S/AS01, Seasonal Malaria Chemoprevention and of the Two Interventions Combined

TypeinterventionalSponsorLondon School of Hygiene and Tropical MedicineRan2017 to 2020Enrolled5,920ConditionsMalaria,Falciparum, Children, OnlyArmsRABIPUR®, RTS,S/AS01, SMC with SP+AQ, SMC placebo
NCT06173206 phase3completednot on this mapstarted 2024, after this paper: background citation

Effect of Single-course Malaria Chemoprevention on Clearance of and Protection From Plasmodium Falciparum Infection in the Presence of Resistance-associated Genotypes in Cameroon

TypeinterventionalSponsorLondon School of Hygiene and Tropical MedicineRan2024 to 2025Enrolled902ConditionsMalariaArmsSP (Macleods Pharmaceuticals Ltd), SPAQ (Guilin Pharmaceuticals), AS (Guilin Pharmaceuticals)
3 · Its place in the literature

Who cites it

84 citing papers in PubMed, 4 syntheses or guidelines pooled it, 162 citations in OpenAlex.

  1. Systematic Review and Meta-Analysis of Seasonal Malaria Chemoprevention.The American journal of tropical medicine and hygiene · 2024
    Pooled it
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  3. Intermittent preventive antimalarial treatment for children with anaemia.The Cochrane database of systematic reviews · 2015
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24 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Anne L WilsonLondon School of Hygiene and Tropical Medicine, London, United Kingdom.
IPTc Taskforce
London School of Hygiene & Tropical Medicine · GB

Funding

Medical Research Council MC_UP_A900_1118
6 · The paper itself

Abstract

backgroundIntermittent preventive treatment of malaria in children less than five years of age (IPTc) has been investigated as a measure to control the burden of malaria in the Sahel and sub-Sahelian areas of Africa where malaria transmission is markedly seasonal. METHODS AND

findingsIPTc studies were identified using a systematic literature search. Meta-analysis was used to assess the protective efficacy of IPTc against clinical episodes of falciparum malaria. The impact of IPTc on all-cause mortality, hospital admissions, severe malaria and the prevalence of parasitaemia and anaemia was investigated. Three aspects of safety were also assessed: adverse reactions to study drugs, development of drug resistance and loss of immunity to malaria. Twelve IPTc studies were identified: seven controlled and five non-controlled trials. Controlled studies demonstrated protective efficacies against clinical malaria of between 31% and 93% and meta-analysis gave an overall protective efficacy of monthly administered IPTc of 82% (95%CI 75%-87%) during the malaria transmission season. Pooling results from twelve studies demonstrated a protective effect of IPTc against all-cause mortality of 57% (95%CI 24%-76%) during the malaria transmission season. No serious adverse events attributable to the drugs used for IPTc were observed in any of the studies. Data from three studies that followed children during the malaria transmission season in the year following IPTc administration showed evidence of a slight increase in the incidence of clinical malaria compared to children who had not received IPTc.

conclusionsIPTc is a safe method of malaria control that has the potential to avert a significant proportion of clinical malaria episodes in areas with markedly seasonal malaria transmission and also appears to have a substantial protective effect against all-cause mortality. These findings indicate that IPTc is a potentially valuable tool that can contribute to the control of malaria in areas with markedly seasonal transmission.

Indexed as

Advisory CommitteesAge FactorsAge of OnsetAlgorithmsAntimalarialsChildChild, PreschoolDrug Administration ScheduleHumansInfantMalariaPreventive MedicineTreatment OutcomeAntimalarials

Identifiers

PMID21340029
PMCPMC3038871
OpenAlexW2075937258

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.