ArticleInternational journal of molecular sciences2010
Biological properties of iron oxide nanoparticles for cellular and molecular magnetic resonance imaging.
Article in International journal of molecular sciences, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed.
- The Biomedical Limitations of Magnetic Nanoparticles and a Biocompatible Alternative in the Form of Magnetotactic Bacteria.Journal of functional biomaterials · 2025Review
- Intercomparison of radiosensitization induced by gold and iron oxide nanoparticles in human glioblastoma cells irradiated by 6 MV photons.Scientific reports · 2022Article
- Nanotechnology-Assisted Cell Tracking.Nanomaterials (Basel, Switzerland) · 2022Review
- Biocompatibility, uptake and subcellular localization of bacterial magnetosomes in mammalian cells.Nanoscale advances · 2021Article
- Superparamagnetic Iron Oxide Nanoparticles: Cytotoxicity, Metabolism, and Cellular Behavior in Biomedicine Applications.International journal of nanomedicine · 2021Review
- Hyperthermia-Triggered Gemcitabine Release from Polymer-Coated Magnetite Nanoparticles.Polymers · 2018Article
- Characterization of Magneto-Endosymbionts as MRI Cell Labeling and Tracking Agents.Molecular imaging and biology · 2018Article
- Uptake, distribution, clearance, and toxicity of iron oxide nanoparticles with different sizes and coatings.Scientific reports · 2018Article
- Use of Nanoparticles As Contrast Agents for the Functional and Molecular Imaging of Abdominal Aortic Aneurysm.Frontiers in cardiovascular medicine · 2017Review
- Erlotinib-Conjugated Iron Oxide Nanoparticles as a Smart Cancer-Targeted Theranostic Probe for MRI.Scientific reports · 2016Article
- Re-assessing the enhanced permeability and retention effect in peripheral arterial disease using radiolabeled long circulating nanoparticles.Biomaterials · 2016Article
- Accelerated Blood Clearance Phenomenon Reduces the Passive Targeting of PEGylated Nanoparticles in Peripheral Arterial Disease.ACS applied materials & interfaces · 2016Article
- Iron oxide nanoparticles for neuronal cell applications: uptake study and magnetic manipulations.Journal of nanobiotechnology · 2016Article
- Magnetic Nanoparticles in Cancer Theranostics.Theranostics · 2015Review
- Magnetic resonance imaging contrast of iron oxide nanoparticles developed for hyperthermia is dominated by iron content.International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group · 2014Article
- Apoferritin modified magnetic particles as doxorubicin carriers for anticancer drug delivery.International journal of molecular sciences · 2013Article
- Superparamagnetic iron oxide nanoparticles: amplifying ROS stress to improve anticancer drug efficacy.Theranostics · 2013Article
- Analysis of Lanthanide Complex Dendrimer Conjugates for Bimodal NIR and MRI Imaging.Macromolecules · 2012Article
- Formulation and in vitro characterization of composite biodegradable magnetic nanoparticles for magnetically guided cell delivery.Pharmaceutical research · 2012Article
- Magnetic nanoparticles in magnetic resonance imaging and diagnostics.Pharmaceutical research · 2012Review
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Superparamagnetic iron-oxide particles (SPIO) are used in different ways as contrast agents for magnetic resonance imaging (MRI): Particles with high nonspecific uptake are required for unspecific labeling of phagocytic cells whereas those that target specific molecules need to have very low unspecific cellular uptake. We compared iron-oxide particles with different core materials (magnetite, maghemite), different coatings (none, dextran, carboxydextran, polystyrene) and different hydrodynamic diameters (20-850 nm) for internalization kinetics, release of internalized particles, toxicity, localization of particles and ability to generate contrast in MRI. Particle uptake was investigated with U118 glioma cells und human umbilical vein endothelial cells (HUVEC), which exhibit different phagocytic properties. In both cell types, the contrast agents Resovist, B102, non-coated Fe(3)O(4) particles and microspheres were better internalized than dextran-coated Nanomag particles. SPIO uptake into the cells increased with particle/iron concentrations. Maximum intracellular accumulation of iron particles was observed between 24 h to 36 h of exposure. Most particles were retained in the cells for at least two weeks, were deeply internalized, and only few remained adsorbed at the cell surface. Internalized particles clustered in the cytosol of the cells. Furthermore, all particles showed a low toxicity. By MRI, monolayers consisting of 5000 Resovist-labeled cells could easily be visualized. Thus, for unspecific cell labeling, Resovist and microspheres show the highest potential, whereas Nanomag particles are promising contrast agents for target-specific labeling.
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