ArticleTherapeutic advances in neurological disorders2011
Myoclonic disorders: a practical approach for diagnosis and treatment.
Article in Therapeutic advances in neurological disorders, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 77 papers, 3 of them syntheses that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
77 citing papers in PubMed, 3 syntheses or guidelines pooled it, 202 citations in OpenAlex.
- Drug-Induced Myoclonus: A Systematic Review.Medicina (Kaunas, Lithuania) · 2025Pooled it
- Familial Cortical Myoclonic Tremor and Epilepsy, an Enigmatic Disorder: From Phenotypes to Pathophysiology and Genetics. A Systematic Review.Tremor and other hyperkinetic movements (New York, N.Y.) · 2018Pooled it
- A novel diagnostic approach to patients with myoclonus.Nature reviews. Neurology · 2015Pooled it
- Diagnostic approach and treatment options for myoclonus.Journal of neural transmission (Vienna, Austria : 1996) · 2026Review
- Lansoprazole-Induced Myoclonus.Tremor and other hyperkinetic movements (New York, N.Y.) · 2026Article
- Myoclonus in geriatric dogs and its association with canine cognitive dysfunction: an online survey.Frontiers in veterinary science · 2026Article
- Pregabalin-Induced Myoclonus in a Patient Without Kidney Dysfunction.Case reports in neurological medicine · 2026Article
- Palatal-Lingual-Facial Myoclonus Due to Acute Cortical Infarction in JAK2V617F Positive Myelodysplastic Syndrome.Movement disorders clinical practice · 2025Article
- Unraveling functional neurological disorder in pediatric populations: A systematic review of diagnosis, treatment, and outcomes.World journal of clinical pediatrics · 2025Article
- Myoclonic Dystonia: A Common Phenomenology in the Pleomorphic Movements of Angelman Syndrome.Movement disorders clinical practice · 2025Article
- Evaluation of Cervical Myoclonus in Dogs with Spinal Diseases: 113 Cases (2014-2023).Animals : an open access journal from MDPI · 2025Article
- Adult-Onset Myoclonus: Comparisons and Contrasts in the Inpatient and Outpatient Settings.Tremor and other hyperkinetic movements (New York, N.Y.) · 2025Article
- Recognizing pediatric febrile myoclonus: a video-documented case report and review of the current literature.Frontiers in pediatrics · 2025Article
- Pallidal deep brain stimulation for patients with myoclonus-dystonia without SGCE mutations.Journal of neurology · 2024Article
- Myoclonus: Differential diagnosis and current management.Epilepsia open · 2024Review
- Flapping Tremor: Unraveling Asterixis-A Narrative Review.Medicina (Kaunas, Lithuania) · 2024Review
- A Reappraisal on cortical myoclonus and brief Remarks on myoclonus of different Origins.Clinical neurophysiology practice · 2024Review
- Dexamethasone alleviates etomidate-induced myoclonus by reversing the inhibition of excitatory amino acid transporters.Frontiers in neuroscience · 2024Article
- Dextromethorphan Induced Dystonia: A Rare Case Report.Hospital pharmacy · 2023Article
- A case report and a brief literature review of belly dancer's dyskinesia in a pregnant patient.SAGE open medical case reports · 2023Article
17 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Myoclonus is a sudden, brief, involuntary muscle jerk. It is caused by abrupt muscle contraction, in the case of positive myoclonus, or by sudden cessation of ongoing muscular activity, in the case of negative myoclonus (NM). Myoclonus may be classified in a number of ways, although classification based on the underlying physiology is the most useful from the therapeutic viewpoint. Given the large number of possible causes of myoclonus, it is essential to take a good history, to clinically characterize myoclonus and to look for additional findings on examination in order to limit the list of possible investigations. With regards to the history, the age of onset, the character of myoclonus, precipitating or alleviating factors, family history and associated symptoms and signs are important. On examination, it is important to see whether the myoclonus appears at rest, on keeping posture or during action, to note the distribution of jerks and to look for the stimulus sensitivity. Electrophysiological tests are very helpful in determining whether myoclonus is cortical, subcortical or spinal. A single pharmacological agent rarely control myoclonus and therefore polytherapy with a combination of drugs, often in large dosages, is usually needed. Generally, antiepileptic drugs such as valproate, levetiracetam and piracetam are effective in cortical myoclonus, but less effective in other forms of myoclonus. Clonazepam may be helpful with all types of myoclonus. Focal and segmental myoclonus, irrespective of its origin, may be treated with botulinum toxin injections, with variable success.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.