Evidence map›Paper›PMID 21339899›Full record

ArticleThe open cardiovascular medicine journal2010

The endothelium and its role in regulating vascular tone.

Aamer Sandoo, Jet J C S Veldhuijzen van Zanten, George S Metsios, Douglas Carroll, George D Kitas

Abstract read
In one paragraph

Article in The open cardiovascular medicine journal, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 373 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
373citing papers in PubMed, 6 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

373 citing papers in PubMed, 6 syntheses or guidelines pooled it.

  1. Pooled it
  2. Endotheliopathy in Acute COVID-19 and Long COVID.International journal of molecular sciences · 2023
    Pooled it
  3. Pooled it
  4. Pooled it
  5. Pooled it
  6. Pooled it
  7. Review
  8. Article
  9. Article
  10. Unravelling the Therapeutic Potential of Cysteine for Cardiovascular Health.International journal of molecular sciences · 2026
    Review
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. METTL3 mediates mJournal of advanced research · 2026
    Article
  17. Review
  18. Article
  19. Article
  20. Article

313 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Aamer SandooSchool of Sport and Exercise Sciences, University of Birmingham, Birmingham, West Midlands, United Kingdom.
Jet J C S Veldhuijzen van Zanten
George S Metsios
Douglas Carroll
George D Kitas

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The endothelium forms an important part of the vasculature and is involved in promoting an atheroprotective environment via the complementary actions of endothelial cell-derived vasoactive factors. Disruption of vascular homeostasis can lead to the development of endothelial dysfunction which in turn contributes to the early and late stages of atherosclerosis. In recent years an increasing number of non-invasive vascular tests have been developed to assess vascular structure and function in different clinical populations. The present review aims to provide an insight into the anatomy of the vasculature as well as the underlying endothelial cell physiology. In addition, an in-depth overview of the current methods used to assess vascular function and structure is provided as well as their link to certain clinical populations.

Indexed as

AtherosclerosisCardiovascular DiseaseEndothelial DysfunctionEndotheliumMacrovascular.MicrovascularNitric OxideSmooth muscle

Identifiers

PMID21339899
PMCPMC3040999

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.