ArticlePersonalized medicine2010
Translational systems biology of inflammation: potential applications to personalized medicine.
Article in Personalized medicine, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
29 citing papers in PubMed, 64 citations in OpenAlex.
- Intravenous N-acetylcysteine in pediatric patients with nonacetaminophen acute liver failure: a placebo-controlled clinical trial.Hepatology (Baltimore, Md.) · 2013Trial
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- Assessment of humoral immunity and nutritionally essential trace elements in steady-state sickle cell disease Nigerian children before and afterBlood science (Baltimore, Md.) · 2022Article
- An Updated Theoretical Framework for Vocal Hyperfunction.American journal of speech-language pathology · 2020Article
- Towards a Physiological Scale of Vocal Fold Agent-Based Models of Surgical Injury and Repair: Sensitivity Analysis, Calibration and Verification.Applied sciences (Basel, Switzerland) · 2019Article
- Individual-specific principal component analysis of circulating inflammatory mediators predicts early organ dysfunction in trauma patients.Journal of critical care · 2016Article
- Big data need big theory too.Philosophical transactions. Series A, Mathematical, physical, and engineering sciences · 2016Review
- Augmenting Surgery via Multi-scale Modeling and Translational Systems Biology in the Era of Precision Medicine: A Multidisciplinary Perspective.Annals of biomedical engineering · 2016Review
- Towards the Design of a Patient-Specific Virtual Tumour.Computational and mathematical methods in medicine · 2016Article
- Insights into the Role of Chemokines, Damage-Associated Molecular Patterns, and Lymphocyte-Derived Mediators from Computational Models of Trauma-Induced Inflammation.Antioxidants & redox signaling · 2015Review
- Computational Identification of Mechanistic Factors That Determine the Timing and Intensity of the Inflammatory Response.PLoS computational biology · 2015Article
- Computational Studies of the Intestinal Host-Microbiota Interactome.Computation (Basel, Switzerland) · 2015Article
- Mathematical Modeling of Early Cellular Innate and Adaptive Immune Responses to Ischemia/Reperfusion Injury and Solid Organ Allotransplantation.Frontiers in immunology · 2015Article
- Computational modelling of the inflammatory response in trauma, sepsis and wound healing: implications for modelling resilience.Interface focus · 2014Review
- From data patterns to mechanistic models in acute critical illness.Journal of critical care · 2014Review
- NOD-scidIl2rg (tm1Wjl) and NOD-Rag1 (null) Il2rg (tm1Wjl) : a model for stromal cell-tumor cell interaction for human colon cancer.Digestive diseases and sciences · 2014Article
- Computational Modeling of Inflammation and Wound Healing.Advances in wound care · 2013Article
- In silico modeling: methods and applications to trauma and sepsis.Critical care medicine · 2013Review
- Sepsis: multiple abnormalities, heterogeneous responses, and evolving understanding.Physiological reviews · 2013Article
- Immunophenotype predicts outcome in pediatric acute liver failure.Journal of pediatric gastroenterology and nutrition · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors at 2 institutions in 1 country.
Funding
Abstract
A central goal of industrialized nations is to provide personalized, preemptive and predictive medicine, while maintaining healthcare costs at a minimum. To do so, we must confront and gain an understanding of inflammation, a complex, nonlinear process central to many diseases that affect both industrialized and developing nations. Herein, we describe the work aimed at creating a rational, engineering-oriented and evidence-based synthesis of inflammation geared towards rapid clinical application. This comprehensive approach, which we call 'Translational Systems Biology', to date has been utilized for in silico studies of sepsis, trauma/hemorrhage/traumatic brain injury, acute liver failure and wound healing. This framework has now allowed us to suggest how to modulate acute inflammation in a rational and individually optimized fashion using engineering principles applied to a biohybrid device. We suggest that we are on the cusp of fulfilling the promise of in silico modeling for personalized medicine for inflammatory disease.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.