ArticlePloS one2011
Secondary attack rate of tuberculosis in urban households in Kampala, Uganda.
Article in PloS one, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers, 6 of them syntheses that pooled it.
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Who cites it
51 citing papers in PubMed, 6 syntheses or guidelines pooled it.
- Quantifying within-household tuberculosis transmission: a systematic review and prospective cohort study.International journal of epidemiology · 2026Pooled it
- Molecular detection of rifampicin-resistantFrontiers in medicine · 2024Pooled it
- Prevention of tuberculosis in household members: estimates of children eligible for treatment.Bulletin of the World Health Organization · 2019Pooled it
- Transmission of Mycobacterium Tuberculosis in Households and the Community: A Systematic Review and Meta-Analysis.American journal of epidemiology · 2017Pooled it
- A systematic review of published literature describing factors associated with tuberculosis recurrence in people living with HIV in Africa.African health sciences · 2015Pooled it
- Contact investigation for tuberculosis: a systematic review and meta-analysis.The European respiratory journal · 2013Pooled it
- Importance of cough and M. tuberculosis strain type as risks for increased transmission within households.PloS one · 2014Trial
- Combination interventions to control the tuberculosis epidemic in the Karamoja subregion of Uganda: A modelling analysis.PLOS global public health · 2026Article
- Detect early TB infection, evaluate contacts for TB (DETEC-TB) - a protocol for a prospective cohort study on active case finding for tuberculosis disease and tuberculosis infection source tracing.BMC infectious diseases · 2025Article
- Incidence of tuberculous infection in a TB-endemic city.The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease · 2024Article
- Article
- Understanding tuberculosis transmission and progression: A prospective cohort study of index cases and close contacts in Moldova.PloS one · 2024Article
- Genetic epidemiology of resistance to M. tuberculosis Infection: importance of study design and recent findings.Genes and immunity · 2023Review
- Article
- Tuberculosis in household contacts of tuberculosis patients in sub-Saharan African countries: A systematic review and meta-analysis.Journal of clinical tuberculosis and other mycobacterial diseases · 2022Review
- Bioinformatics mentorship in a resource limited setting.Briefings in bioinformatics · 2022Article
- Excess Risk of Tuberculosis Infection Among Extra-household Contacts of Tuberculosis Cases in an African City.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2021Article
- Article
- Defining an intermediate category of tuberculin skin test: A mixture model analysis of two high-risk populations from Kampala, Uganda.PloS one · 2021Article
- Genetics and evolution of tuberculosis pathogenesis: New perspectives and approaches.Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases · 2020Review
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Authors and funding
8 authors.
Funding
Abstract
backgroundTuberculosis is an ancient disease that continues to threaten individual and public health today, especially in sub-Saharan Africa. Current surveillance systems describe general risk of tuberculosis in a population but do not characterize the risk to an individual following exposure to an infectious case.
methodsIn a study of household contacts of infectious tuberculosis cases (n = 1918) and a community survey of tuberculosis infection (N = 1179) in Kampala, Uganda, we estimated the secondary attack rate for tuberculosis disease and tuberculosis infection. The ratio of these rates is the likelihood of progressive primary disease after recent household infection.
resultsThe secondary attack rate for tuberculosis disease was 3.0% (95% confidence interval: 2.2, 3.8). The overall secondary attack rate for tuberculosis infection was 47.4 (95% confidence interval: 44.3, 50.6) and did not vary widely with age, HIV status or BCG vaccination. The risk for progressive primary disease was highest among the young or HIV infected and was reduced by BCG vaccination.
conclusionsEarly case detection and treatment may limit household transmission of M. tuberculosis. Household members at high risk for disease should be protected through vaccination or treatment of latent tuberculosis infection.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.