ReviewMolecular psychiatry2011
Mechanism of acute tryptophan depletion: is it only serotonin?
Review in Molecular psychiatry, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 69 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
69 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Tryptophan modulation in individuals with attention deficit hyperactivity disorder: a systematic review.Journal of neural transmission (Vienna, Austria : 1996) · 2022Pooled it
- Effects of tryptophan depletion on anxiety, a systematic review.Translational psychiatry · 2021Pooled it
- The effects of acute tryptophan depletion on instrumental reward learning in anorexia nervosa - an fMRI study.Psychological medicine · 2023Trial
- Trial
- Serotonin depletion impairs both Pavlovian and instrumental reversal learning in healthy humans.Molecular psychiatry · 2021Trial
- Effect of Tryptophan Depletion on Conditioned Threat Memory Expression: Role of Intolerance of Uncertainty.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2021Trial
- Serotonin depletion amplifies distinct human social emotions as a function of individual differences in personality.Translational psychiatry · 2021Trial
- Acute tryptophan loading decreases functional connectivity between the default mode network and emotion-related brain regions.Human brain mapping · 2019Trial
- Measuring endogenous changes in serotonergic neurotransmission with [Translational psychiatry · 2019Trial
- Effects of biperiden and acute tryptophan depletion and their combination on verbal word memory and EEG.Psychopharmacology · 2017Trial
- Cortico-limbic connectivity in MAOA-L carriers is vulnerable to acute tryptophan depletion.Human brain mapping · 2017Trial
- Serotoninergic effects on judgments and social learning of trustworthiness.Psychopharmacology · 2014Trial
- Serotonin depletion induces 'waiting impulsivity' on the human four-choice serial reaction time task: cross-species translational significance.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2014Trial
- Acute tryptophan depletion promotes an anterior-to-posterior fMRI activation shift during task switching in older adults.Human brain mapping · 2014Trial
- Serotonin 2A receptors, citalopram and tryptophan-depletion: a multimodal imaging study of their interactions during response inhibition.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2013Trial
- Acute tryptophan depletion in accordance with body weight: influx of amino acids across the blood-brain barrier.Journal of neural transmission (Vienna, Austria : 1996) · 2012Trial
- Acute tryptophan depletion increases translational indices of anxiety but not fear: serotonergic modulation of the bed nucleus of the stria terminalis?Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2012Trial
- Serotonin selectively modulates reward value in human decision-making.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2012Trial
- Effects of acute tryptophan depletion on prefrontal-amygdala connectivity while viewing facial signals of aggression.Biological psychiatry · 2012Trial
- The influence of serotonin on fear learning.PloS one · 2012Trial
9 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The method of acute tryptophan depletion (ATD), which reduces the availability of the essential amino acid tryptophan (TRP), the dietary serotonin (5-hydroxytryptamine (5-HT)) precursor, has been applied in many experimental studies. ATD application leads to decreased availability of TRP in the brain and its synthesis into 5-HT. It is therefore assumed that a decrease in 5-HT release and subsequent blunted neurotransmission is the underlying mechanism for the behavioural effects of ATD. However, direct evidence that ATD decreases extracellular 5-HT concentrations is lacking. Furthermore, several studies provide support for alternative underlying mechanisms of ATD. This may question the utility of the method as a selective serotonergic challenge tool. As ATD is extensively used for investigating the role of 5-HT in cognitive functions and psychiatric disorders, the potential of alternative mechanisms and possible confounding factors should be taken into account. It is suggested that caution is required when interpreting ATD effects in terms of a selective serotonergic effect.
Indexed as
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.