ArticleFly
Meiotic checkpoints and the interchromosomal effect on crossing over in Drosophila females.
Article in Fly. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 24 citations in OpenAlex.
- Article
- Meiosis through three centuries.Chromosoma · 2024Review
- Article
- Does the Pachytene Checkpoint, a Feature of Meiosis, Filter Out Mistakes in Double-Strand DNA Break Repair and as a side-Effect Strongly Promote Adaptive Speciation?Integrative organismal biology (Oxford, England) · 2022Article
- Recombination suppression in heterozygotes for a pericentric inversion induces the interchromosomal effect on crossovers in Arabidopsis.The Plant journal : for cell and molecular biology · 2019Article
- Article
- Recombination rate plasticity: revealing mechanisms by design.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2017Review
- Early development of Drosophila embryos requires Smc5/6 function during oogenesis.Biology open · 2016Article
- Meiotic recombination and the crossover assurance checkpoint in Caenorhabditis elegans.Seminars in cell & developmental biology · 2016Review
- Meiotic crossover patterns: obligatory crossover, interference and homeostasis in a single process.Cell cycle (Georgetown, Tex.) · 2015Review
- Crossover patterning by the beam-film model: analysis and implications.PLoS genetics · 2014Article
- Untangling the web: the diverse functions of the PIWI/piRNA pathway.Molecular reproduction and development · 2013Review
- Pch2 acts through Xrs2 and Tel1/ATM to modulate interhomolog bias and checkpoint function during meiosis.PLoS genetics · 2011Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
During prophase of meiosis I, genetic recombination is initiated with a Spo11-dependent DNA double-strand break (DSB). Repair of these DSBs can generate crossovers, which become chiasmata and are important for the process of chromosome segregation. To ensure at least one chiasma per homologous pair of chromosomes, the number and distribution of crossovers is regulated. One system contributing to the distribution of crossovers is the pachytene checkpoint, which requires the conserved gene pch2 that encodes an AAA+ATPase family member. Pch2-dependent pachytene checkpoint function causes delays in pachytene progression when there are defects in processes required for crossover formation, such as mutations in DSB-repair genes and when there are defects in the structure of the meiotic chromosome axis. Thus, the pachytene checkpoint appears to monitor events leading up to the generation of crossovers. Interestingly, heterozygous chromosome rearrangements cause Pch2-dependent pachytene delays and as little as two breaks in the continuity of the paired chromosome axes are sufficient to evoke checkpoint activity. These chromosome rearrangements also cause an interchromosomal effect on recombination whereby crossing over is suppressed between the affected chromosomes but is increased between the normal chromosome pairs. We have shown that this phenomenon is also due to pachytene checkpoint activity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.