Evidence map›Paper›PMID 21339639›Full record

ArticleThe Journal of clinical investigation2011

Upper urinary tract pacemaker cells join the GLI club.

Doris Herzlinger

Open access · bronzeAbstract readComment
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of clinical investigation, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.4field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
  2. Review
  3. Lower urinary tract development and disease.Wiley interdisciplinary reviews. Systems biology and medicine
    Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

1 author at 1 institution in 1 country.

Doris HerzlingerDepartment of Physiology and Biophysics, Cornell University Medical College, New York, New York 10021-4805, USA. daherzli@med.cornell.edu
Cornell University · US

Funding

Urogenital System Development: The Acquisition of Coordinated Ureter PeristalsisR01DK045218 · NIDDK · WEILL MEDICAL COLL OF CORNELL UNIV · PI HERZLINGER, DORIS A · 1991 to 2015
$5.7M
Resource Development Center: Real Time Imaging of Urinary Tract Smooth Muscle FunP20DK103072 · NIDDK · WEILL MEDICAL COLL OF CORNELL UNIV · PI HERZLINGER, DORIS A · 2014 to 2015
$678k
ALDOSTERONE REGULATION OF SODIUM TRANSPORT IN THE KIDNEYK08DK002723 · NIDDK · UNIVERSITY OF CALIFORNIA SAN FRANCISCO · PI ROZANSKY, DAVID J · 1999 to 2003
$503k
GENERATION OF RENAL EPITHELIAL CELL DIVERSITYR55DK045218 · NIDDK · WEILL MEDICAL COLLEGE OF CORNELL UNIV · PI HERZLINGER, DORIS A · 1994 to 1994
–
NIDDK NIH HHS DK02723NIDDK NIH HHS DK45218NIDDK NIH HHS K08 DK002723NIDDK NIH HHS P20 DK103072NIDDK NIH HHS R01 DK045218
6 · The paper itself

Abstract

Mutations in GLI3, a component of the Sonic Hedgehog (Shh) signaling pathway, cause a variety of human developmental syndromes. In this issue of the JCI, Cain and colleagues show that tightly regulated GLI3 repressor activity is essential for Shh-dependent differentiation of upper urinary tract pacemaker cells and the efficient flow of urine from the kidney to the bladder. These results link defective pacemaker cell differentiation with hydronephrosis and provide a cellular basis for one of the abnormal renal defects observed in humans with the GLI3-linked disease Pallister-Hall syndrome.

Indexed as

AnimalsCell DifferentiationElectrophysiologyGene Expression Regulation, DevelopmentalHedgehog ProteinsHumansKidneyKruppel-Like Transcription FactorsModels, BiologicalMuscle ContractionMuscle, SmoothNerve Tissue ProteinsPallister-Hall SyndromeUrinary BladderUrinary TractZinc Finger Protein Gli3GLI3 protein, humanHedgehog ProteinsKruppel-Like Transcription FactorsNerve Tissue ProteinsSHH protein, humanZinc Finger Protein Gli3

Identifiers

PMID21339639
PMCPMC3049378
OpenAlexW2075642476

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.