ArticleThe Journal of clinical investigation2011
Adherent-invasive E. coli in Crohn disease: bacterial "agent provocateur".
Article in The Journal of clinical investigation, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 34 citations in OpenAlex.
- Gut Microbiota in Irritable Bowel Syndrome and Inflammatory Bowel Disease: Differences in Pathophysiology, Biomarkers, and Treatment Implications.Pharmaceuticals (Basel, Switzerland) · 2026Review
- An adult zebrafish model for adherent-invasiveiScience · 2022Article
- Article
- The Changing Face of the FamilyClinical microbiology reviews · 2021Review
- Neutrophil activation by Escherichia coli isolates from human intestine: effects of bacterial hydroperoxidase activity and surface hydrophobicity.FEBS open bio · 2020Article
- Propionate Induces Virulent Properties of Crohn's Disease-AssociatedFrontiers in microbiology · 2020Article
- Dysbiosis Disrupts Gut Immune Homeostasis and Promotes Gastric Diseases.International journal of molecular sciences · 2019Review
- Investigation of adherent-invasiveMedical journal of the Islamic Republic of Iran · 2018Article
- Tumor necrosis factor α-induced protein 3 (A20) is dysregulated in pediatric Crohn disease.Clinical and experimental gastroenterology · 2018Article
- Mechanisms of Intestinal Epithelial Barrier Dysfunction by Adherent-InvasiveCellular and molecular gastroenterology and hepatology · 2017Review
- Crohn's disease and sarcoidosis in siblings: follow-up of a published report with a new case and brief review of the literature.Frontline gastroenterology · 2017Article
- Prevalence of Mycobacterium avium subsp. paratuberculosis and Escherichia coli in blood samples from patients with inflammatory bowel disease.Medical microbiology and immunology · 2015Article
- Diet and Inflammatory Bowel Disease.Gastroenterology & hepatology · 2015Article
- The IbeA invasin of adherent-invasive Escherichia coli mediates interaction with intestinal epithelia and macrophages.Infection and immunity · 2015Article
- Host-microbe interactions in the small bowel.Current opinion in gastroenterology · 2015Review
- Article
- Crohn's disease-associated Escherichia coli survive in macrophages by suppressing NFκB signaling.Inflammatory bowel diseases · 2014Article
- Effector triggered manipulation of host immune response elicited by different pathotypes of Escherichia coli.Virulence · 2014Review
- Impact of the gut microbiome on mucosal inflammation.Trends in immunology · 2013Review
- Immunomodulation for gastrointestinal infections.Expert review of anti-infective therapy · 2012Review
Corrections and comments
- Comment on
Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
The role of adherent-invasive E. coli (AIEC) in Crohn disease (CD) has been in debate for decades. AIEC bacteria are found in the small intestine of patients with chronic CD, but it has remained unclear whether this infection is causal or secondary to underlying immune deficiencies in CD patients. In this issue of the JCI, Chassaing and colleagues demonstrate that AIEC bacteria express an adherence factor called long polar fimbriae (LPF) that aids in the binding of these bacteria to M cells overlying Peyer's patches and subsequent entry into lymphoid tissue. These findings provide a mechanism of AIEC penetration but do not prove that AIEC is causing a primary infection in the Peyer's patches that is necessary for the initiation or persistence of CD inflammation.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.