ArticleJournal of physics. Condensed matter : an Institute of Physics journal2010
Control and reversal of the electrophoretic force on DNA in a charged nanopore.
Article in Journal of physics. Condensed matter : an Institute of Physics journal, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
22 citing papers in PubMed.
- Beyond the Continuum Theory: Conductance Scaling and Correlated Imaging in Atom-Scale Artificial Ion Channels.ACS nano · 2026Article
- Polymer Translocation and Nanopore Sequencing: A Review of Advances and Challenges.International journal of molecular sciences · 2023Review
- Article
- On the origins of conductive pulse sensing inside a nanopore.Nature communications · 2022Article
- Profiling single-molecule reaction kinetics under nanopore confinement.Chemical science · 2022Article
- Spontaneous DNA translocation through a van der Waals heterostructure nanopore for single-molecule detection.Nanoscale advances · 2021Article
- DNA translocation through pH-dependent soft nanopores.European biophysics journal : EBJ · 2021Article
- How Nanopore Translocation Experiments Can Measure RNA Unfolding.Biophysical journal · 2020Article
- Next Generation Sequencing and Machine Learning Technologies Are Painting the Epigenetic Portrait of Glioblastoma.Frontiers in oncology · 2020Review
- Solid-state nanopore hydrodynamics and transport.Biomicrofluidics · 2019Article
- Surveying silicon nitride nanopores for glycomics and heparin quality assurance.Nature communications · 2018Article
- Mechanical Trapping of DNA in a Double-Nanopore System.Nano letters · 2016Article
- Role of Electroosmosis in the Permeation of Neutral Molecules: CymA and Cyclodextrin as an Example.Biophysical journal · 2016Article
- DNA stretching and optimization of nucleobase recognition in enzymatic nanopore sequencing.Nanotechnology · 2015Article
- DNA motion induced by electrokinetic flow near an Au coated nanopore surface as voltage controlled gate.Nanotechnology · 2015Article
- Close encounters with DNA.Journal of physics. Condensed matter : an Institute of Physics journal · 2014Review
- Modeling and simulation of ion channels.Chemical reviews · 2012Review
- Toward detection of DNA-bound proteins using solid-state nanopores: insights from computer simulations.Electrophoresis · 2012Article
- Ion transport through a graphene nanopore.Nanotechnology · 2012Article
- Review
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
Electric field driven transport of DNA through solid-state nanopores is the key process in nanopore-based DNA sequencing that promises dramatic reduction of genome sequencing costs. A major hurdle in the development of this sequencing method is that DNA transport through the nanopores occurs too quickly for the DNA sequence to be detected. By means of all-atom molecular dynamics simulations, we demonstrate that the velocity of DNA transport through a nanopore can be controlled by the charge state of the nanopore surface. In particular, we show that the charge density of the nanopore surface controls the magnitude and/or direction of the electro-osmotic flow through the nanopore and thereby can significantly reduce or even reverse the effective electrophoretic force on DNA. Our work suggests a physical mechanism to control DNA transport in a nanopore by chemical, electrical or electrochemical modification of the nanopore surface.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.