ArticleJournal of immunology (Baltimore, Md. : 1950)2011
T cell factor-1 negatively regulates expression of IL-17 family of cytokines and protects mice from experimental autoimmune encephalomyelitis.
Article in Journal of immunology (Baltimore, Md. : 1950), 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers.
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Who cites it
44 citing papers in PubMed, 64 citations in OpenAlex.
- Transcription factor TCF1 binds to RORγt and orchestrates a regulatory network that determines homeostatic Th17 cell state.Immunity · 2024Article
- The multifaceted roles of TCF1 in innate and adaptive lymphocytes.Advances in immunology · 2024Review
- WNT-β Catenin Signaling as a Potential Therapeutic Target for Neurodegenerative Diseases: Current Status and Future Perspective.Diseases (Basel, Switzerland) · 2023Review
- miR-aculous new avenues for cancer immunotherapy.Frontiers in immunology · 2022Review
- Cell-intrinsic and -extrinsic roles of miRNAs in regulating T cell immunity.Immunological reviews · 2021Review
- The intervention of intestinal Wnt/β-catenin pathway alters inflammation and disease severity of CIA.Immunologic research · 2021Article
- Title of article: Mucosal-associated invariant T cells in lung diseases.International immunopharmacology · 2021Review
- Transcription tipping points for T follicular helper cell and T-helper 1 cell fate commitment.Cellular & molecular immunology · 2021Review
- Stepwise Tfh cell differentiation revisited: new advances and long-standing questions.Faculty reviews · 2021Article
- Induction of IL-22-Producing CD4+ T Cells by Segmented Filamentous Bacteria Independent of Classical Th17 Cells.Frontiers in immunology · 2021Article
- T cell factor 1: A master regulator of the T cell response in disease.Science immunology · 2020Review
- c-Maf regulates the plasticity of group 3 innate lymphoid cells by restraining the type 1 program.The Journal of experimental medicine · 2020Article
- TCF-1 limits the formation of Tc17 cells via repression of the MAF-RORγt axis.The Journal of experimental medicine · 2019Article
- The transcription factor c-Maf is essential for the commitment of IL-17-producing γδ T cells.Nature immunology · 2019Article
- Canonical and Non-Canonical Wnt Signaling in Immune Cells.Trends in immunology · 2018Review
- TCF-1 Inhibits IL-17 Gene Expression To Restrain Th17 Immunity in a Stage-Specific Manner.Journal of immunology (Baltimore, Md. : 1950) · 2018Article
- The Th17 Lineage: From Barrier Surfaces Homeostasis to Autoimmunity, Cancer, and HIV-1 Pathogenesis.Viruses · 2017Review
- A Novel miR-24-TCF1 Axis in Modulating Effector T Cell Responses.Journal of immunology (Baltimore, Md. : 1950) · 2017Article
- MiR-34a promotes DCs development and inhibits their function on T cell activation by targeting WNT1.Oncotarget · 2017Article
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Activated CD4 T cells are associated with protective immunity and autoimmunity. The manner in which the inflammatory potential of T cells and resultant autoimmunity is restrained is poorly understood. In this article, we demonstrate that T cell factor-1 (TCF1) negatively regulates the expression of IL-17 and related cytokines in activated CD4 T cells. We show that TCF1 does not affect cytokine signals and expression of transcription factors that have been shown to regulate Th17 differentiation. Instead, TCF1 regulates IL-17 expression, in part, by binding to the regulatory regions of the Il17 gene. Moreover, TCF1-deficient Th17 CD4 T cells express higher levels of IL-7Rα, which potentially promotes their survival and expansion in vivo. Accordingly, TCF1-deficient mice are hyperresponsive to experimental autoimmune encephalomyelitis. Thus, TCF1, a constitutively expressed T cell-specific transcription factor, is a critical negative regulator of the inflammatory potential of TCR-activated T cells and autoimmunity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.