ArticleRadiology2011
Septic arthritis: monitoring with USPIO-enhanced macrophage MR imaging.
Article in Radiology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 38 citations in OpenAlex.
- MRI findings of treated bacterial septic arthritis.Skeletal radiology · 2012Trial
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- Ex vivo magnetic particle imaging of vascular inflammation in abdominal aortic aneurysm in a murine model.Scientific reports · 2020Article
- A Review of Magnetic Particle Imaging and Perspectives on Neuroimaging.AJNR. American journal of neuroradiology · 2019Review
- Visualization and quantification ofTheranostics · 2019Article
- Applications of Iron Oxide-Based Magnetic Nanoparticles in the Diagnosis and Treatment of Bacterial Infections.Frontiers in bioengineering and biotechnology · 2019Review
- The Role of MR Enterography in Assessing Crohn's Disease Activity and Treatment Response.Gastroenterology research and practice · 2016Review
- Iron-based superparamagnetic nanoparticle contrast agents for MRI of infection and inflammation.AJR. American journal of roentgenology · 2015Review
- Magnetic particle imaging: current developments and future directions.International journal of nanomedicine · 2015Review
- Monitoring the effects of dexamethasone treatment by MRI using in vivo iron oxide nanoparticle-labeled macrophages.Arthritis research & therapy · 2014Article
- In vivo macrophage imaging using MR targeted contrast agent for longitudinal evaluation of septic arthritis.Journal of visualized experiments : JoVE · 2013Article
- Imaging evaluation of inflammation in the musculoskeletal system: current concepts and perspectives.Skeletal radiology · 2013Review
- MRI confirms loss of blood-brain barrier integrity in a mouse model of disseminated candidiasis.NMR in biomedicine · 2013Article
- Magnetic resonance imaging of soft tissue infection with iron oxide labeled granulocytes in a rat model.PloS one · 2012Article
- What's New in the Management of Bacterial Septic Arthritis?Current infectious disease reports · 2011Article
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeTo prospectively evaluate in vivo noninvasive monitoring of antibiotic therapy in experimental infectious arthritis by imaging macrophages by using magnetic resonance (MR) imaging enhanced with ultrasmall superparamagnetic iron oxide (USPIO) particles. MATERIALS AND
methodsThe institutional review committee on animal care approved the experimental protocol. Unilateral knee infection was induced by intra-articular injection of Staphylococcus aureus in 12 rabbits. Each rabbit underwent MR imaging before and after injection of USPIO particles, as well as before and after injection of gadoterate meglumine. All 12 of the animals were imaged during the acute phase of infection. Half were then sacrificed to obtain histopathologic samples, and the other half were imaged a second time after antibiotic treatment. MR imaging data were analyzed and compared with bacteriologic and histopathologic findings.
resultsIn acute infections, intense synovitis with marked signal intensity increase of the synovium on gadoterate dimeglumine-enhanced fat-suppressed T1-weighted images was observed in all animals and was associated with areas of signal intensity loss within the infected synovium on USPIO-enhanced T2*-weighted gradient-echo images, reflecting an intense infiltration of USPIO-loaded macrophages. After antibiotic treatment and histologic evidence of healing infection, less synovial signal intensity loss was seen (P = .03). In contradistinction, the signal intensity increase on gadoterate dimeglumine-enhanced fat-suppressed T1-weighted images remained unchanged.
conclusionIn contrast to conventional MR imaging performed by using extracellular contrast agents, USPIO-enhanced macrophage MR imaging can demonstrate resolution of experimental bacterial joint infection.
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