ArticlePediatrics2011
Ohio statewide quality-improvement collaborative to reduce late-onset sepsis in preterm infants.
Article in Pediatrics, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 54 papers, 4 of them syntheses that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
54 citing papers in PubMed, 4 syntheses or guidelines pooled it.
- Pooled it
- Early planned removal versus expectant management of peripherally inserted central catheters to prevent infection in newborn infants.The Cochrane database of systematic reviews · 2018Pooled it
- Antimicrobial-impregnated central venous catheters for prevention of catheter-related bloodstream infection in newborn infants.The Cochrane database of systematic reviews · 2015Pooled it
- Antibiotic lock for the prevention of catheter-related infection in neonates.The Cochrane database of systematic reviews · 2015Pooled it
- Prevention of neonatal late-onset sepsis: a randomised controlled trial.BMC pediatrics · 2017Trial
- From lines to lifelines: a quality improvement study to reduce CLABSI at a level III NICU in LMIC.BMJ open quality · 2026Article
- Article
- Transitioning medically complex infants home: lessons learned from quality improvement efforts.Journal of perinatology : official journal of the California Perinatal Association · 2025Article
- Racial and Ethnic Differences in Outcomes of Neonates Born at Less Than 30 Weeks' Gestation, 2018-2022.JAMA network open · 2024Article
- [A quality improvement project on reducing antibiotic use duration in very low birth weight preterm infants in the neonatal intensive care unit].Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2024Article
- Building a regional pediatric asthma learning health system in support of optimal, equitable outcomes.Learning health systems · 2024Article
- Antiseptic solutions for skin preparation during central catheter insertion in neonates.The Cochrane database of systematic reviews · 2023Review
- Experiences of a Regional Quality Improvement Collaborative to Reduce Unplanned Extubations in the Neonatal Intensive Care Unit.Children (Basel, Switzerland) · 2022Article
- Article
- Epidermal Immunity and Function: Origin in Neonatal Skin.Frontiers in molecular biosciences · 2022Review
- Reducing healthcare-associated infections by improving compliance to aseptic non-touch technique in intravenous line maintenance: a quality improvement approach.BMJ open quality · 2021Article
- Reducing late-onset neonatal sepsis in very low birthweight neonates with central lines in a low-and-middle-income country setting.BMJ open quality · 2021Article
- Risk Factors for Mortality From Late-Onset Sepsis Among Preterm Very-Low-Birthweight Infants: A Single-Center Cohort Study From Singapore.Frontiers in pediatrics · 2021Article
- Creating a Multisite Perinatal Psychiatry Databank: Purpose and Development.International journal of environmental research and public health · 2020Article
- Maternal activation of the EGFR prevents translocation of gut-residing pathogenicProceedings of the National Academy of Sciences of the United States of America · 2020Article
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5 authors.
Funding
Abstract
objectiveWe aimed to reduce late-onset bacterial infections in infants born at 22 to 29 weeks' gestation by using collaborative quality-improvement methods to implement evidence-based catheter care. We hypothesized that these methods would result in a 50% reduction in nosocomial infection. PATIENTS AND
methodsWe conducted an interrupted time-series study among 24 Ohio NICUs. The intervention began in September 2008 and continued through December 2009. Sites used the Institute for Healthcare Improvement Breakthrough Series quality-improvement model to facilitate implementation of evidence-based catheter care. Data were collected monthly for all catheter insertions and for at least 10 observations of indwelling catheter care. NICUs also submitted monthly data on catheter-days, patient-days, and episodes of infection. Data were analyzed by using statistical process control methods.
resultsDuring the intervention, NICUs submitted information on 1916 infants. Of the 242 infections reported, 69% were catheter associated. Compliance with catheter-insertion components was >90% by April 2009. Compliance with components of evidence-based indwelling catheter care reached 80.4% by December 2009. There was a significant reduction in the proportion of infants with at least 1 late-onset infection from a baseline of 18.2% to 14.3%.
conclusionsThere was a 20% reduction in the incidence of late-onset infection after the intervention, but the magnitude was less than hypothesized, perhaps because compliance with components of evidence-based care of indwelling catheters remained <90%. Because nearly one-third of infections were not catheter associated, improvement may require attention to other aspects of care such as skin integrity and nutrition.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.