ReviewNeuron2011
Reward mechanisms in obesity: new insights and future directions.
Review in Neuron, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 326 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
326 citing papers in PubMed, 2 syntheses or guidelines pooled it, 738 citations in OpenAlex.
- Exposure to PMInternational journal of environmental research and public health · 2021Pooled it
- Biomolecules and Electrochemical Tools in Chronic Non-Communicable Disease Surveillance: A Systematic Review.Biosensors · 2020Pooled it
- Intranasal insulin enhances resting-state functional connectivity in Type 2 Diabetes.PloS one · 2025Trial
- Association of Changes in Neural Targets and Dietary Outcomes among Patients with Comorbid Obesity and Depression: Post hoc Analysis of ENGAGE-2 Mechanistic Clinical Trial.The Journal of nutrition · 2023Trial
- The motilin agonist erythromycin increases hunger by modulating homeostatic and hedonic brain circuits in healthy women: a randomized, placebo-controlled study.Scientific reports · 2018Trial
- Oxytocin enhances cognitive control of food craving in women.Human brain mapping · 2016Trial
- Article
- Hyperdopaminergic States Bias Explorations-Exploitation Trade-Off in Foraging and Impair Survival.The European journal of neuroscience · 2026Article
- Using Best-Worst Scaling to explore the perceived addictiveness of foods by processing level: a cross-sectional study among higher education students in Belgium.Archives of public health = Archives belges de sante publique · 2026Article
- Differential brain response to a highly palatable drink in chronic low back pain patients.Journal of neurophysiology · 2026Article
- Application ofBiomolecules & therapeutics · 2026Review
- Ventral pallidal GABAergic neurons control hedonic feeding and obesity.bioRxiv : the preprint server for biology · 2026Article
- Intermittency and Predictability of a Cafeteria Diet Shape Food Intake, Adiposity, and Neurobehavioral Outcomes in Rats.Nutrients · 2026Article
- Weight maintenance after discontinuation of GLP-1 therapies.EClinicalMedicine · 2026Review
- A larger amount of palatable food is needed to provide stress relief during Western diet-induced obesity.Physiology & behavior · 2026Article
- Dopamine D2 receptor modulation of insulin receptor signaling in the central amygdala: implications for compulsive-like eating behavior.Molecular psychiatry · 2026Article
- Revisiting food addiction in the era of GLP-1-based obesity pharmacotherapy via neural reward pathways linking feeding and substance use.Frontiers in behavioral neuroscience · 2026Review
- Sex-specific alterations in CRF and dopaminergic markers in the lateral septum and mesolimbic system following chronic high-fat diet exposure in rats.Frontiers in pharmacology · 2026Article
- When cues take the wheel: cue-control across alcohol use disorder, binge-eating disorder, gambling disorder, and internet gaming disorder.Frontiers in psychology · 2026Review
- Brain activity associated with breakthrough food preoccupation in an individual on tirzepatide.Nature medicine · 2025Article
266 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
Food is consumed in order to maintain energy balance at homeostatic levels. In addition, palatable food is also consumed for its hedonic properties independent of energy status. Such reward-related consumption can result in caloric intake exceeding requirements and is considered a major culprit in the rapidly increasing rates of obesity in developed countries. Compared with homeostatic mechanisms of feeding, much less is known about how hedonic systems in brain influence food intake. Intriguingly, excessive consumption of palatable food can trigger neuroadaptive responses in brain reward circuitries similar to drugs of abuse. Furthermore, similar genetic vulnerabilities in brain reward systems can increase predisposition to drug addiction and obesity. Here, recent advances in our understanding of the brain circuitries that regulate hedonic aspects of feeding behavior will be reviewed. Also, emerging evidence suggesting that obesity and drug addiction may share common hedonic mechanisms will also be considered.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.