ReviewFrontiers in neuroendocrinology2011
Cooperation of sex chromosomal genes and endocrine influences for hypothalamic sexual differentiation.
Review in Frontiers in neuroendocrinology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
28 citing papers in PubMed, 47 citations in OpenAlex.
- Sex chromosomes and hormones independently influence healthy brain development but act similarly after cranial radiation.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Female aging: when translational models don't translate.Nature aging · 2023Review
- Evaluating different models of maternal stress on stress-responsive systems in prepubertal mice.Frontiers in neuroscience · 2023Article
- Gonadal hormone-independent sex differences in GABABritish journal of pharmacology · 2020Article
- Estradiol-dependent axogenesis and Ngn3 expression are determined by XY sex chromosome complement in hypothalamic neurons.Scientific reports · 2020Article
- Effects of Sex Steroids in the Human Brain.Molecular neurobiology · 2017Review
- Neuroendocrine disruption of organizational and activational hormone programming in poikilothermic vertebrates.Journal of toxicology and environmental health. Part B, Critical reviews · 2017Review
- The importance of having two X chromosomes.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2016Review
- Cellular and molecular mechanisms of sexual differentiation in the mammalian nervous system.Frontiers in neuroendocrinology · 2016Review
- The Influence of Gonadal Steroid Hormones on Immunoreactive Kisspeptin in the Preoptic Area and Arcuate Nucleus of Developing Agonadal Mice with a Genetic Disruption of Steroidogenic Factor 1.Neuroendocrinology · 2016Article
- A path forward in the debate over health impacts of endocrine disrupting chemicals.Environmental health : a global access science source · 2014Article
- Gonadectomy prior to puberty decreases normal parental behavior in adult mice.Hormones and behavior · 2014Article
- Conceptual frameworks and mouse models for studying sex differences in physiology and disease: why compensation changes the game.Experimental neurology · 2014Review
- Gender-dependent resiliency to stressful and metabolic challenges following prenatal exposure to high-fat diet in the p66(Shc-/-) mouse.Frontiers in behavioral neuroscience · 2014Article
- Disruption of fetal hormonal programming (prenatal stress) implicates shared risk for sex differences in depression and cardiovascular disease.Frontiers in neuroendocrinology · 2014Review
- Fetal hormonal programming of sex differences in depression: linking women's mental health with sex differences in the brain across the lifespan.Frontiers in neuroscience · 2014Article
- Cell-autonomous sex determination outside of the gonad.Developmental dynamics : an official publication of the American Association of Anatomists · 2013Review
- Volumetric parcellation methodology of the human hypothalamus in neuroimaging: normative data and sex differences.NeuroImage · 2013Article
- Sexual differentiation in the developing mouse brain: contributions of sex chromosome genes.Genes, brain, and behavior · 2013Article
- Nutrient-dependent/pheromone-controlled adaptive evolution: a model.Socioaffective neuroscience & psychology · 2013Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 2 countries.
Funding
Abstract
There is little debate that mammalian sexual differentiation starts from the perspective of two primary sexes that correspond to differential sex chromosomes (X versus Y) that lead to individuals with sex typical characteristics. Sex steroid hormones account for most aspects of brain sexual differentiation, however, a growing literature has raised important questions about the role of sex chromosomal genes separate from sex steroid actions. Several important model animals are being used to address these issues and, in particular, they are taking advantage of molecular genetic approaches using different mouse strains. The current review examines the cooperation of genetic and endocrine influences from the perspective of behavioral and morphological hypothalamic sexual differentiation, first in adults and then in development. In the final analysis, there is an ongoing need to account for the influence of hormones in the context of underlying genetic circumstances and null hormone conditions.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.