ArticleHuman brain mapping2012
Direct optic nerve pulvinar connections defined by diffusion MR tractography in humans: implications for photophobia.
Article in Human brain mapping, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
47 citing papers in PubMed, 1 synthesis or guideline pooled it, 81 citations in OpenAlex.
- Methods of diffusion MRI tractography for localization of the anterior optic pathway: A systematic review of validated methods.NeuroImage. Clinical · 2023Pooled it
- Functional ultrasound imaging reveals early pathway-specific reorganization of central visual circuits in a mouse model of Batten disease.Neurobiology of disease · 2026Article
- Functional ultrasound imaging reveals pathway-specific visual system reorganization in youngbioRxiv : the preprint server for biology · 2026Article
- Article
- Article
- Light-eye-body axis: exploring the network from retinal illumination to systemic regulation.Theranostics · 2025Review
- Light Therapy in Chronic Migraine.Current pain and headache reports · 2024Review
- FL-41 Tint Reduces Activation of Neural Pathways of Photophobia in Patients with Chronic Ocular Pain.American journal of ophthalmology · 2024Article
- Light modulates task-dependent thalamo-cortical connectivity during an auditory attentional task.Communications biology · 2023Article
- Exploring sensory sensitivity, cortical excitability, and habituation in episodic migraine, as a function of age and disease severity, using the pattern-reversal task.The journal of headache and pain · 2023Article
- CGRP physiology, pharmacology, and therapeutic targets: migraine and beyond.Physiological reviews · 2023Review
- Narrow band green light effects on headache, photophobia, sleep, and anxiety among migraine patients: an open-label study conducted online using daily headache diary.Frontiers in neurology · 2023Article
- Photophobia in headache disorders: characteristics and potential mechanisms.Journal of neurology · 2022Review
- Comparison of multiple tractography methods for reconstruction of the retinogeniculate visual pathway using diffusion MRI.Human brain mapping · 2021Article
- Disrupted connectivity within visual, attentional and salience networks in the visual snow syndrome.Human brain mapping · 2021Article
- Supraspinal Mechanisms Underlying Ocular Pain.Frontiers in medicine · 2021Review
- Alternative Microstructural Measures to Complement Diffusion Tensor Imaging in Migraine Studies with Standard MRI Acquisition.Brain sciences · 2020Article
- Article
- Altered lateral geniculate nucleus functional connectivity in migraine without aura: a resting-state functional MRI study.The journal of headache and pain · 2020Article
- Current understanding of thalamic structure and function in migraine.Cephalalgia : an international journal of headache · 2019Review
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
The pathway that underlies exacerbation of migraine headache by light has not been elucidated in the human brain but has recently been reported in a rodent model. We employ diffusion weighted imaging and probabilistic tractography to map connectivity of direct pathways from the optic nerve to the pulvinar implicated with whole-body allodynia during migraine. Nine healthy subjects were recruited to the study and underwent scanning on a 3T magnet. We were able to define well-known image-forming (optic nerve -> lateral geniculate -> visual cortex) as well as a less known nonimage forming visual pathway from the optic chiasm to the pulvinar, and from the pulvinar to several associative cortical brain regions. Such pathway may allow photic signals to converge on a thalamic region we described recently to be selectively activated during migraine headache. Consistent with physiological and anatomical studies in rats, the data provide an anatomical substrate for exacerbation of migraine headache by light in the human.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.