ArticleThe international journal of cardiovascular imaging2012
Polymorphic variation in choline transporter gene (CHT1) is associated with early, subclinical measures of carotid atherosclerosis in humans.
Article in The international journal of cardiovascular imaging, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 16 citations in OpenAlex.
- Transport mechanism of presynaptic high-affinity choline uptake by CHT1.Nature structural & molecular biology · 2024Article
- Metabolomics study in severe extracranial carotid artery stenosis.BMC neurology · 2019Article
- Polymorphic variation in the SLC5A7 gene influences infant autonomic reactivity and self-regulation: A neurobiological model for ANS stress responsivity and infant temperament.Psychoneuroendocrinology · 2018Article
- Role of High-affinity Choline Transporter 1 in Colonic Hypermotility in a Rat Model of Irritable Bowel Syndrome.Journal of neurogastroenterology and motility · 2018Article
- Upregulation of the high-affinity choline transporter in colon relieves stress-induced hyperalgesia.Journal of pain research · 2018Article
- Differential impact of genetically modulated choline transporter expression on the release of endogenous versus newly synthesized acetylcholine.Neurochemistry international · 2016Article
- Cholinergic genetics of visual attention: Human and mouse choline transporter capacity variants influence distractibility.Journal of physiology, Paris · 2016Review
- Synthesis and structure-activity relationships of a series of 4-methoxy-3-(piperidin-4-yl)oxy benzamides as novel inhibitors of the presynaptic choline transporter.Bioorganic & medicinal chemistry letters · 2015Article
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
Abstract
Atherosclerosis is a heritable trait with little known about specific genetic influences on preclinical measures of plaque formation. Based on relations of parasympathetic-cholinergic function to atherosclerosis and to a choline transporter gene [CHT1 (G/T)] polymorphism, we investigated whether the same allelic variant predicts variation in carotid intima-media thickness (IMT) and plaque formation. Carotid IMT and plaque occurrence as well as genotyping for the CHT1 (G/T) variant were measured in a sample (N = 264) of generally healthy adults (age 30-55) of European ancestry. CHT1 GG homozygotes had greater IMT (P < 0.005) and plaque occurrence (P < 0.020) than T allele carriers. This is the first study showing polymorphic variation in the CHT1 gene to predict early, subclinical measures of carotid atherosclerosis which may aid in understanding cholinergic-vagal processes potentially underlying atherosclerotic risk.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.