ReviewJournal of molecular medicine (Berlin, Germany)2011
Hypoxia: a double-edged sword of immunity.
Review in Journal of molecular medicine (Berlin, Germany), 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
27 citing papers in PubMed, 63 citations in OpenAlex.
- Interactions between sleep, inflammation, immunity and infections: A narrative review.Immunity, inflammation and disease · 2024Review
- Article
- Review
- Article
- Review
- Distinct Residential and Infiltrated Macrophage Populations and Their Phagocytic Function in Mild and Severe Neonatal Hypoxic-Ischemic Brain Damage.Frontiers in cellular neuroscience · 2020Article
- Genome-wide analysis sheds light on the high-altitude adaptation of the buff-throated partridge (Tetraophasis szechenyii).Molecular genetics and genomics : MGG · 2020Article
- Current Strategies to Target Tumor-Associated-Macrophages to Improve Anti-Tumor Immune Responses.Cells · 2019Review
- M2 microglia-derived exosomes protect the mouse brain from ischemia-reperfusion injury via exosomal miR-124.Theranostics · 2019Article
- The Involvement and Therapy Target of Immune Cells After Ischemic Stroke.Frontiers in immunology · 2019Review
- Hypoxia-inducible transcription factors, HIF1A and HIF2A, increase in aging mucosal tissues.Immunology · 2018Article
- Mitochondrial function of immune cells in septic shock: A prospective observational cohort study.PloS one · 2017Article
- Microglia and Monocyte-Derived Macrophages in Stroke.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2016Review
- Regulation of Langerhans cell functions in a hypoxic environment.Journal of molecular medicine (Berlin, Germany) · 2016Article
- Article
- Article
- Shape descriptors of the "never resting" microglia in three different acute brain injury models in mice.Intensive care medicine experimental · 2015Article
- The ischemic environment drives microglia and macrophage function.Frontiers in neurology · 2015Review
- Effects of vitamin C on the hypobaric hypoxia-induced immune changes in male rats.International journal of biometeorology · 2014Article
- Positive correlation of STAT1 and miR-146a with anemia in patients with systemic lupus erythematosus.Journal of clinical immunology · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Hypoxia is a condition of low oxygen tension that characterizes virtually every site of inflammation, tissue damage, and neoplasia. Hypoxic environment attracts infiltrating immune cells that move against oxygen gradients and respond to these demanding conditions by switching to anaerobic metabolism to maintain their energy requirements. Several lines of evidence suggest that oxygen deprivation causes opposite effects on the innate or adaptive immune responses. We will review the evidence that the hypoxic environment promotes the recruitment, activation, and survival of innate immune cells while inhibiting the adaptive immunity through downregulation of effector lymphocyte functions. This divergent regulation of the innate and adaptive immunity appears to reflect evolutionary mechanisms aimed to both guarantee tissue homeostasis and provide safeguard mechanisms against autoimmunity. Selective inhibition of hypoxic signaling pathways in myeloid versus lymphoid cells may open new therapeutic opportunities in diseases characterized by low oxygen tension.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.